Pan Zhaoquan, Tan Weiqiang, Ran Xiaoke, Yan Mingyue, Xie Fengxi
Guangxi University of Chinese Medicine, Guangxi, China.
Guangzhou University of Chinese Medicine, Guangzhou, China.
Clin Rehabil. 2025 Mar;39(3):281-294. doi: 10.1177/02692155241310750. Epub 2025 Jan 7.
ObjectiveTo systematically evaluate the efficacy of hyperbaric oxygen therapy for non-motor symptoms in patients with Parkinson's disease.Data sourcesA systematic search was performed across several databases, including the Chinese Science and Technology Periodical Database, Web of Science, SinoMed, PubMed, Cochrane Library, Embase and Wanfang databases up to 1 December 2024. Studies considered for inclusion comprised randomised controlled trials and pre-post control studies.Review methodsThe authors conducted the data extraction and literature screening procedures independently. The selected studies' quality was evaluated using the Cochrane risk of bias technique. Review Manager 5.3 was used to conduct meta-analyses, while Stata 15.0 was utilised for sensitivity analysis and to assess publication bias.ResultsSixteen studies with a total of 1324 individuals satisfied the inclusion criteria. The results of the meta-analysis showed that hyperbaric oxygen therapy significantly improved scores on the Hamilton Anxiety Scale and Hamilton Depression Scale compared with baseline (both < 0.05). Additionally, improvements were observed in the Montreal Cognitive Assessment, Mini-Mental State Examination, Parkinson's Disease Sleep Scale, Pittsburgh Sleep Quality Index, Kubota's Drinking Water Test and Unified Parkinson's Disease Rating Scale III. Improvements in sleep efficiency and extension of total sleep time were also noted compared with controls (all < 0.05).ConclusionThe findings indicate that hyperbaric oxygen therapy effectively alleviates non-motor symptoms such as anxiety, depression, cognitive impairments, sleep disturbances, and swallowing dysfunction, as well as improving motor function in Parkinson's disease patients. Since the hyperbaric oxygen therapy protocol had significant differences between studies, further prospective randomised controlled trials with rigorous methodology are needed.
目的
系统评价高压氧治疗帕金森病患者非运动症状的疗效。
资料来源
对多个数据库进行了系统检索，包括中国科技期刊数据库、科学网、中国生物医学文献数据库、PubMed、考克兰图书馆、Embase和万方数据库，检索截至2024年12月1日。纳入的研究包括随机对照试验和前后对照研究。
综述方法
作者独立进行数据提取和文献筛选程序。使用考克兰偏倚风险技术评估所选研究的质量。使用Review Manager 5.3进行荟萃分析，同时使用Stata 15.0进行敏感性分析并评估发表偏倚。
结果
16项研究共1324例个体符合纳入标准。荟萃分析结果显示，与基线相比，高压氧治疗显著改善了汉密尔顿焦虑量表和汉密尔顿抑郁量表的评分（均P<0.05）。此外，蒙特利尔认知评估、简易精神状态检查表、帕金森病睡眠量表、匹兹堡睡眠质量指数、久保田饮水试验和统一帕金森病评定量表Ⅲ也有改善。与对照组相比，睡眠效率提高和总睡眠时间延长也有记录（均P<0.05）。
结论
研究结果表明，高压氧治疗可有效缓解帕金森病患者的焦虑、抑郁、认知障碍、睡眠障碍和吞咽功能障碍等非运动症状，并改善运动功能。由于不同研究的高压氧治疗方案存在显著差异，因此需要进一步开展方法严谨的前瞻性随机对照试验。
