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咖啡摄入量与常见精神障碍之间的关联:遗传分析的见解

Association Between Coffee Intake and Common Mental Disorders: Insights From Genetic Analysis.

作者信息

Du Zhiqiang, Jiang Ying, Shen Yuan, Zhou Qin, Gong Peng, Zhu Haohao

机构信息

Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, China.

出版信息

CNS Neurosci Ther. 2025 Jan;31(1):e70213. doi: 10.1111/cns.70213.

Abstract

The study found a significant causal relationship between coffee intake and obsessive-compulsive disorder, showing a negative correlation. There was no causal relationship between coffee intake and other mental disorders. The sensitivity analysis test found no pleiotropy affecting the results, and no single nucleotide polymorphism had a major impact on the robustness of the results, indicating that the results are stable and reliable.

摘要

该研究发现咖啡摄入量与强迫症之间存在显著的因果关系,呈负相关。咖啡摄入量与其他精神障碍之间不存在因果关系。敏感性分析测试未发现影响结果的多效性,且没有单核苷酸多态性对结果的稳健性有重大影响,表明结果稳定可靠。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa0/11705407/6c21a965657e/CNS-31-e70213-g001.jpg

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