Freedman David E, Oh Jiwon, Feinstein Anthony
Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Canada.
Division of Neurology, Department of Medicine, St. Michael's Hospital, and Division of Neurology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Mult Scler Relat Disord. 2025 Feb;94:106245. doi: 10.1016/j.msard.2024.106245. Epub 2024 Dec 21.
Although depression and anxiety are common in people with multiple sclerosis (pwMS), access to psychotherapy remains limited.
This study aimed to identify clinical factors that predict use of psychotherapy among pwMS.
From a retrospective chart review of a tertiary neuropsychiatry clinic in Toronto, Canada, data were obtained for 267 pwMS who received neuropsychiatric treatment (either with antidepressants or psychotherapy). Candidate predictor variables included demographics (e.g. age, sex), disease-related factors (e.g. disease duration, MS subtype, Expanded Disability Status Scale (EDSS) score), symptom data (e.g. Hospital Anxiety and Depression Scale sub-scales for anxiety and depression, five-item Modified Fatigue Impact Scale), and other treatment use (e.g. disease-modifying therapies, psychotropic medications). A backward stepwise logistic regression analysis identified predictors of psychotherapy use (p<.05).
Mean age was 46.97 years, 70.41 % were female, median EDSS was 2.50, 63.30 % had relapsing illness, and 22.47 % received psychotherapy. Increased EDSS scores (OR=0.74, 95 % CI 0.58-0.95, p=.02) and prolonged disease duration (OR=0.94, 95 % CI 0.89-0.99, p=.03) predicted decreased use of psychotherapy.
Neurological disability and disease duration may influence psychotherapy use among pwMS. Studies are now needed to evaluate contributors to these associations to expand access to non-pharmacological treatments for pwMS.
尽管抑郁症和焦虑症在多发性硬化症患者(pwMS)中很常见,但心理治疗的可及性仍然有限。
本研究旨在确定预测pwMS患者使用心理治疗的临床因素。
通过对加拿大多伦多一家三级神经精神病诊所的回顾性病历审查,获取了267名接受神经精神治疗(使用抗抑郁药或心理治疗)的pwMS患者的数据。候选预测变量包括人口统计学特征(如年龄、性别)、疾病相关因素(如病程、MS亚型、扩展残疾状态量表(EDSS)评分)、症状数据(如医院焦虑抑郁量表焦虑和抑郁子量表、五项改良疲劳影响量表)以及其他治疗使用情况(如疾病修饰疗法、精神药物)。向后逐步逻辑回归分析确定了心理治疗使用的预测因素(p<0.05)。
平均年龄为46.97岁,70.41%为女性,EDSS中位数为2.50,63.30%患有复发型疾病,22.47%接受了心理治疗。EDSS评分升高(OR=0.74,95%CI 0.58-0.95,p=0.02)和病程延长(OR=0.94,95%CI 0.89-0.99,p=0.03)预测心理治疗使用减少。
神经功能障碍和病程可能会影响pwMS患者对心理治疗的使用。现在需要开展研究来评估这些关联的影响因素,以扩大pwMS患者获得非药物治疗的机会。