Lee Kelly S W, Zhang Qingyang, Suwa Tatsuya, Clark Heather, Olcina Monica M
Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom.
Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom.
Semin Immunol. 2025 Mar;77:101927. doi: 10.1016/j.smim.2024.101927. Epub 2025 Jan 6.
The complement system is increasingly recognised as a key player in tumour progression and response to cancer treatment. Cytotoxic therapies, including chemo- and radiotherapy are standard-of-care for the majority of cancer patients. Cytotoxics have been found to alter the expression of complement system proteins and activation of components. Many recent reports highlight the role of local dysregulation of complement proteins in the tumour microenvironment and how targeting such dysregulation can have either anti- or pro-tumoricidal effects depending on several factors including treatment scheduling, the tumour type and its microenvironment characteristics. This review will explore the complex effects of cytotoxic therapy on complement regulation and what lessons can be learnt to identify the most effective way to therapeutically modulate complement system proteins for cancer therapy.
补体系统越来越被认为是肿瘤进展和癌症治疗反应中的关键参与者。细胞毒性疗法，包括化疗和放疗，是大多数癌症患者的标准治疗方法。已发现细胞毒性药物会改变补体系统蛋白的表达和成分的激活。最近许多报告强调了肿瘤微环境中补体蛋白局部失调的作用，以及根据治疗方案、肿瘤类型及其微环境特征等多种因素，靶向这种失调如何产生抗肿瘤或促肿瘤杀伤作用。本综述将探讨细胞毒性疗法对补体调节的复杂影响，以及可以吸取哪些经验教训来确定治疗性调节补体系统蛋白以用于癌症治疗的最有效方法。
