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五种柑橘皮精油的抗氧化、抗炎和抗癌活性

Antioxidant, Anti-Inflammatory, and Anticancer Activities of Five Citrus Peel Essential Oils.

作者信息

Li Yurong, Li Wenji, Ye Zimao, Ji Chen, Zhou Zhiqin

机构信息

Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River, Ministry of Education, College of Horticulture and Landscape Architecture, Southwest University, Beibei District, Chongqing 400715, China.

School of Design, Chongqing Industry Polytechnic College, Chongqing 401120, China.

出版信息

Antioxidants (Basel). 2024 Dec 19;13(12):1562. doi: 10.3390/antiox13121562.

DOI:10.3390/antiox13121562
PMID:39765890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11672981/
Abstract

Citrus peel essential oil (CPEO) is favored by people for its aromatic scent, while also possessing numerous bioactive compounds that are advantageous to human health. This study evaluated the antioxidant, anti-inflammatory, and anticancer activities of CPEOs through cell experiments. The results showed that CPEOs could increase the activity of the antioxidant enzyme system and nonenzymatic defence system in HO-treated RAW 264.7 cells by reducing cellular lipid peroxidation. CPEOs also reduced the nitric oxide production induced by lipopolysaccharide treatment in RAW 264.7 cells while decreasing proinflammatory cytokines expression and increasing anti-inflammatory cytokine expression. Wound healing assays, flow cytometry, and quantitative real-time fluorescent quantitative PCR (qRT-PCR) revealed that CPEOs could induce apoptosis in U87 cells through the mitochondrial apoptotic pathway. These findings indicate that CPEOs possess excellent antioxidant, anti-inflammatory, and anticancer activity potential, making them suitable for use in functional antioxidant and anti-inflammatory foods and nutritional health products.

摘要

柑橘皮精油（CPEO）因其芳香气味而受到人们喜爱，同时还拥有许多对人体健康有益的生物活性化合物。本研究通过细胞实验评估了CPEO的抗氧化、抗炎和抗癌活性。结果表明，CPEO可通过减少细胞脂质过氧化，提高经过氧化氢（HO）处理的RAW 264.7细胞中抗氧化酶系统和非酶防御系统的活性。CPEO还降低了脂多糖处理诱导的RAW 264.7细胞中一氧化氮的产生，同时减少促炎细胞因子表达并增加抗炎细胞因子表达。伤口愈合试验、流式细胞术和实时荧光定量PCR（qRT-PCR）显示，CPEO可通过线粒体凋亡途径诱导U87细胞凋亡。这些发现表明，CPEO具有优异的抗氧化、抗炎和抗癌活性潜力，使其适用于功能性抗氧化和抗炎食品以及营养保健品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/b8ff84574515/antioxidants-13-01562-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/a827065dcd85/antioxidants-13-01562-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/09b37c0189ed/antioxidants-13-01562-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/087e98fa21b0/antioxidants-13-01562-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/8910b88286ce/antioxidants-13-01562-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/81a7327c8386/antioxidants-13-01562-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/7637eddc3819/antioxidants-13-01562-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/b8ff84574515/antioxidants-13-01562-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/a827065dcd85/antioxidants-13-01562-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/09b37c0189ed/antioxidants-13-01562-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/087e98fa21b0/antioxidants-13-01562-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/8910b88286ce/antioxidants-13-01562-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/81a7327c8386/antioxidants-13-01562-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/7637eddc3819/antioxidants-13-01562-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7051/11672981/b8ff84574515/antioxidants-13-01562-g007.jpg

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Antioxidant, Anti-Inflammatory, and Anticancer Activities of Five Citrus Peel Essential Oils.

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本文引用的文献

[1]
Molecular interactions between metformin and D-limonene inhibit proliferation and promote apoptosis in breast and liver cancer cells.

BMC Complement Med Ther. 2024-5-6

[2]
In Vitro Antiviral and Anticancer Effects of Tanacetum sinaicum Essential Oil on Human Cervical and Breast Cancer.

Asian Pac J Cancer Prev. 2024-4-1

[3]
Enrichment of milk antioxidant activity by dietary supplementation of red clover isoflavone in cows and its improvement on mice intestinal health.

Food Chem. 2024-7-15

[4]
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Molecules. 2023-9-21

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Molecules. 2023-9-6

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Autophagy. 2023-12

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Combination of tamoxifen and D-limonene enhances therapeutic efficacy in breast cancer cells.

Med Oncol. 2023-6-30

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Nutriepigenomics in Environmental-Associated Oxidative Stress.

Antioxidants (Basel). 2023-3-21

[9]
The Chemical Variability, Nutraceutical Value, and Food-Industry and Cosmetic Applications of Citrus Plants: A Critical Review.

Antioxidants (Basel). 2023-2-14

[10]
β-Myrcene Mitigates Colon Inflammation by Inhibiting MAP Kinase and NF-κB Signaling Pathways.

Molecules. 2022-12-9

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