Brandon J M, Raval P J
Eur J Pharmacol. 1979 Aug 1;57(2-3):171-7. doi: 10.1016/0014-2999(79)90362-5.
The relationship between estrogen and histamine in the initiation of ovum implantation in the rat was studied. Histamine was found to augment the implantation response to suboptimal doses of estradiol in the ovariectomized pregnant rat maintained with Depo-Provera. The effect of histamine was found to involve both H1- and H2-receptors and to be inhibited by treatment with a combination of mepyramine and metiamide. Treatment with this combination of histamine antagonists during early pregnancy in the intact rat did not modify blastocyst attachment. It was concluded that the effect of histamine on the implantation response to exogenous estradiol was due to increased uterine blood flow and/or estrogen uptake but that such histamine-mediated effects were not essential for blastocyst attachment during normal pregnancy.
研究了雌激素与组胺在大鼠卵子着床起始过程中的关系。在接受醋酸甲羟孕酮维持的去卵巢妊娠大鼠中，发现组胺可增强对次优剂量雌二醇的着床反应。发现组胺的作用涉及H1和H2受体，并可被甲氧苄二胺和甲硫米特联合治疗所抑制。在未孕大鼠的妊娠早期用这种组胺拮抗剂联合治疗，并未改变胚泡着床。得出的结论是，组胺对外源雌激素着床反应的影响是由于子宫血流量增加和/或雌激素摄取增加，但这种组胺介导的作用对于正常妊娠期间胚泡着床并非必不可少。
