Tamminen Anselm, Boström Pia
Department of Plastic and General Surgery, Turku University Hospital, 20520 Turku, Finland.
Department of Surgery, University of Turku, 20014 Turku, Finland.
Cancers (Basel). 2024 Dec 20;16(24):4246. doi: 10.3390/cancers16244246.
(1) Low-grade adenosquamous carcinoma (LGASC) is a rare subtype of metaplastic breast carcinoma (MpBC), accounting for fewer than 0.05% of breast cancer cases. Unlike the typically aggressive nature of MpBCs, LGASC is an indolent tumor with an excellent prognosis. Due to its rarity, LGASC is frequently misdiagnosed, particularly in core needle biopsies. Currently, there are no clear treatment guidelines for LGASC. (2) Methods: This study presents a single-center retrospective analysis and a systematic literature review of LGASC. (3) Results: Three LGASC cases were diagnosed among 6462 breast cancer patients in our center, demonstrating its rarity. LGASC has overlapping features with benign sclerosing lesions and is often initially misdiagnosed. LGASC is often overtreated, as its indolent nature is not recognized. It very rarely presents axillary or distant metastases, and in contemporary data, local recurrences are rare, questioning the need for adjuvant therapy. (4) Conclusions: LGASC is a very rare form of breast cancer with an excellent prognosis despite being MpBC and usually a triple-negative breast cancer. It is often overtreated as its unique nature is not recognized.
（1）低级别腺鳞癌（LGASC）是化生性乳腺癌（MpBC）的一种罕见亚型，占乳腺癌病例的比例不到0.05%。与典型的侵袭性MpBC不同，LGASC是一种惰性肿瘤，预后良好。由于其罕见性，LGASC经常被误诊，尤其是在粗针活检中。目前，尚无针对LGASC的明确治疗指南。（2）方法：本研究对LGASC进行了单中心回顾性分析和系统文献综述。（3）结果：在我们中心的6462例乳腺癌患者中诊断出3例LGASC病例，显示出其罕见性。LGASC与良性硬化性病变有重叠特征，且常最初被误诊。LGASC常被过度治疗，因为其惰性本质未被认识到。它很少出现腋窝或远处转移，在当代数据中，局部复发也很少见，这对辅助治疗的必要性提出了质疑。（4）结论：LGASC是一种非常罕见的乳腺癌形式，尽管它是MpBC且通常是三阴性乳腺癌，但预后良好。由于其独特本质未被认识到，它常被过度治疗。
