Arleo Andrea, Montagner Annapaola, Giovannini Catia, Suzzi Fabrizia, Piscaglia Fabio, Gramantieri Laura
Department of Medical and Surgical Sciences, Bologna University, 40138 Bologna, Italy.
Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Biomolecules. 2024 Nov 24;14(12):1496. doi: 10.3390/biom14121496.
Myelopoiesis provides for the formation and continued renewal of cells belonging primarily to the innate immune system. It is a highly plastic process that secures the response to external and internal stimuli to face acute and changing needs. Infections and chronic diseases including cancer can modulate it by producing several factors, impacting proliferation and differentiation programs. While the lymphocytic compartment has attracted major attention due to the role of adaptive immunity in anticancer immune response, in recent years, research has found convincing evidence that confirms the importance of innate immunity and the key function played by emergency myelopoiesis. Due to cancer's ability to manipulate myelopoiesis to its own advantage, the purpose of this review is to outline myelopoiesis processes within the tumor microenvironment and suggest possible therapeutic lines of research to restore the physiological functioning of the host's immune system, with a special outlook on hepatocellular carcinoma (HCC).
髓系造血为主要属于先天免疫系统的细胞的形成和持续更新提供支持。它是一个高度可塑性的过程，能确保对外部和内部刺激做出反应，以应对急性和不断变化的需求。感染和包括癌症在内的慢性疾病可通过产生多种因子来调节髓系造血，影响增殖和分化程序。虽然由于适应性免疫在抗癌免疫反应中的作用，淋巴细胞区室已引起了主要关注，但近年来，研究已发现令人信服的证据，证实了先天免疫的重要性以及应急髓系造血所发挥的关键作用。由于癌症有能力将髓系造血操纵为自身所用，本综述的目的是概述肿瘤微环境中的髓系造血过程，并提出可能的治疗研究方向，以恢复宿主免疫系统的生理功能，特别是针对肝细胞癌（HCC）。
