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减重手术对2型糖尿病患者血浆基质金属蛋白酶水平的影响。

The Influence of Bariatric Surgery on Matrix Metalloproteinase Plasma Levels in Patients with Type 2 Diabetes Mellitus.

作者信息

Gentile João Kleber de Almeida, Migliore Renato, Waisberg Jaques, Ribeiro Junior Marcelo Augusto Fontenelle

机构信息

Departament of Surgery, Institute of Infectology Emilio Ribas (IIER), São Paulo 01246-900, SP, Brazil.

Department of Surgery, Hospital São Camilo, São Paulo 02401-200, SP, Brazil.

出版信息

Biomolecules. 2024 Dec 19;14(12):1633. doi: 10.3390/biom14121633.

DOI:10.3390/biom14121633
PMID:39766340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11727344/
Abstract

BACKGROUND

Bariatric surgery is a safe and effective procedure for treating obesity and metabolic conditions such as type 2 (T2DM). Remodeling of the extracellular matrix (ECM) supports adipose tissue expansion and its metabolic activity, where matrix metalloproteinases (MMPs) play a key role in ECM regulation. The MMPs, particularly MMP-2 and MMP-9, are elevated in patients with morbid obesity, metabolic syndrome, and T2DM.

OBJECTIVES

To evaluate the effect of weight loss in bariatric surgery patients using oxidative stress markers and to compare MMP levels in patients undergoing bariatric surgery.

METHODS

This was a prospective, controlled study including 45 morbidly obese patients with T2DM (BMI > 35 kg/m) who underwent RYGB (n = 24) or VG (n = 21). Weight loss was assessed through anthropometric measurements (weight, height, BMI). MMP-2 and MMP-9 levels were measured preoperatively and at 3 and 12 months postoperatively.

RESULTS

Significant and sustained weight loss was observed after surgery in both groups, with reductions in BMI. MMP-2 and MMP-9 levels decreased significantly after one year of follow-up.

CONCLUSIONS

Bariatric surgery is an effective long-term intervention for weight loss and associated comorbidities, including T2DM. MMP-2 and MMP-9 proved to be effective markers of extracellular matrix remodeling, with significant reductions following surgery.

摘要

背景

减重手术是治疗肥胖症和2型糖尿病（T2DM）等代谢性疾病的一种安全有效的方法。细胞外基质（ECM）的重塑支持脂肪组织扩张及其代谢活动，其中基质金属蛋白酶（MMPs）在ECM调节中起关键作用。在病态肥胖、代谢综合征和T2DM患者中，MMPs，尤其是MMP-2和MMP-9水平升高。

目的

使用氧化应激标志物评估减重手术患者体重减轻的效果，并比较接受减重手术患者的MMP水平。

方法

这是一项前瞻性对照研究，纳入45例患有T2DM的病态肥胖患者（BMI>35 kg/m²），他们接受了Roux-en-Y胃旁路术（RYGB，n = 24）或垂直袖状胃切除术（VG，n = 21）。通过人体测量（体重、身高、BMI）评估体重减轻情况。术前及术后3个月和12个月测量MMP-2和MMP-9水平。

结果

两组术后均观察到显著且持续的体重减轻，BMI降低。随访一年后，MMP-2和MMP-9水平显著降低。

结论

减重手术是一种有效的长期干预措施，可减轻体重并治疗包括T2DM在内的相关合并症。MMP-2和MMP-9被证明是细胞外基质重塑的有效标志物，术后显著降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13c/11727344/65d073f65398/biomolecules-14-01633-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13c/11727344/9a4bf33319a8/biomolecules-14-01633-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13c/11727344/ede9fd860aa4/biomolecules-14-01633-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13c/11727344/65d073f65398/biomolecules-14-01633-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13c/11727344/9a4bf33319a8/biomolecules-14-01633-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13c/11727344/ede9fd860aa4/biomolecules-14-01633-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13c/11727344/65d073f65398/biomolecules-14-01633-g003.jpg

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