Zhao Hai, Kang Xuejun
Key Laboratory of Child Development and Learning Science (Ministry of Education), School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, China.
Brain Sci. 2024 Dec 21;14(12):1290. doi: 10.3390/brainsci14121290.
Growing evidence suggests a link between organophosphate insecticides and depression disorder. These chemicals are metabolized and subsequently expelled through the urinary tract. The present study aims to investigate whether dialkyl phosphate metabolites associate with depression score and severity among the general population.
This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES). Depression was evaluated by the Patient Health Questionnaire-9 (PHQ-9). All urinary dialkyl phosphate metabolites were quantitatively analyzed. The survey's complex design parameters and sampling weights were considered.
3035 eligible individuals were included. The estimated prevalence of mild and major depression was 18.3% (95% confidence interval [CI]: 16.9-19.7%) and 9.9% (95% CI: 8.7-11.0%). For each incremental unit in the level of urinary dimethyl phosphate (DMP), individuals were found to have a higher depression score of 0.77 and a significantly increased odds ratio (OR) of 1.13 (95% CI: 1.12-1.13) for mild depression and 2.75 (95% CI: 2.74-2.76) for major depression.
Our findings indicate positive and independent associations between urinary dialkyl phosphate metabolites and an elevated risk of depression among the general population.
越来越多的证据表明有机磷杀虫剂与抑郁症之间存在联系。这些化学物质会被代谢，随后通过尿道排出。本研究旨在调查二烷基磷酸酯代谢物是否与普通人群的抑郁评分及严重程度相关。
这项横断面研究使用了来自美国国家健康与营养检查调查（NHANES）的数据。通过患者健康问卷-9（PHQ-9）评估抑郁情况。对所有尿液中的二烷基磷酸酯代谢物进行定量分析。考虑了该调查的复杂设计参数和抽样权重。
纳入了3035名符合条件的个体。轻度和重度抑郁症的估计患病率分别为18.3%（95%置信区间[CI]：16.9 - 19.7%）和9.9%（95%CI：8.7 - 11.0%）。尿液中二甲基磷酸酯（DMP）水平每增加一个单位，个体的抑郁评分会升高0.77，轻度抑郁症的优势比（OR）显著增加1.13（95%CI：1.12 - 1.13），重度抑郁症的优势比为2.75（95%CI：2.74 - 2.76）。
我们的研究结果表明，尿液中的二烷基磷酸酯代谢物与普通人群中抑郁症风险升高之间存在正向且独立的关联。
