Department of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China.
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, China.
Front Endocrinol (Lausanne). 2021 Jul 28;12:650988. doi: 10.3389/fendo.2021.650988. eCollection 2021.
To investigate the association of dynamic weight change in adulthood with leukocyte telomere length among U.S. adults.
This study included 3,886 subjects aged 36-75 years from the National Health and Nutrition Examination Survey (NHANES) 1999-2002 cycle. Survey-weighted multivariable linear regression with adjustments for potential confounders was utilized.
3,386 individuals were finally included. People with stable obesity had a 0.130 kbp (95% CI: 0.061-0.198, =1.97E-04) shorter leukocyte telomere length than those with stable normal weight (reference group) during the 10-year period, corresponding to approximately 8.7 years of aging. Weight gain from non-obesity to obesity shortened the leukocyte telomere length by 0.094 kbp (95% CI: 0.012-0.177, =0.026), while normal weight to overweight or remaining overweight shortened the leukocyte telomere length by 0.074 kbp (95% CI: 0.014-0.134, =0.016). The leukocyte telomere length has 0.003 kbp attrition on average for every 1 kg increase in weight from a mean age of 41 years to 51 years. Further stratified analysis showed that the associations generally varied across sex and race/ethnicity.
This study found that weight changes during a 10-year period was associated with leukocyte telomere length and supports the theory that weight gain promotes aging across adulthood.
探讨美国成年人成年后体重动态变化与白细胞端粒长度的关系。
本研究纳入了来自 1999-2002 年全国健康和营养调查（NHANES）的 3886 名年龄在 36-75 岁的成年人。采用调整了潜在混杂因素的调查加权多变量线性回归进行分析。
最终纳入 3386 人。在 10 年期间，稳定肥胖的人群与稳定正常体重的人群（参考组）相比，白细胞端粒长度缩短了 0.130 kbp（95%CI：0.061-0.198，=1.97E-04），相当于衰老了 8.7 年。从非肥胖到肥胖的体重增加使白细胞端粒长度缩短了 0.094 kbp（95%CI：0.012-0.177，=0.026），而从正常体重到超重或持续超重使白细胞端粒长度缩短了 0.074 kbp（95%CI：0.014-0.134，=0.016）。从平均年龄 41 岁到 51 岁，体重每增加 1 公斤，白细胞端粒长度平均缩短 0.003 kbp。进一步的分层分析表明，这些关联在性别和种族/民族之间存在差异。
本研究发现，10 年内的体重变化与白细胞端粒长度有关，支持体重增加会促进成年人整体衰老的理论。
