Bond G G, Shellenberger R J, Flores G H, Cook R R, Fishbeck W A
Am J Ind Med. 1985;7(2):123-39. doi: 10.1002/ajim.4700070205.
An in-plant case-control study of 26 renal cancer deaths was conducted to determine whether an occupational exposure may be related to an apparent increase in mortality from this disease observed among a sample of employees at a multiple process chemical production facility. None was found that explained the excess. Elevated odds ratios were identified for employment in the cell maintenance area of chlorine production and with those presumptive exposures considered to occur in this job, asbestos and caustic, but not chlorine. While an association between renal cancer and asbestos has been previously reported, an association with caustic, per se, is not consistent with prior observations made by others. Diminished risk estimates were observed for employment in magnesium production and for exposures in this process to sulfur dioxide and heat. Both the increased and decreased risks, while statistically significant, are based on small numbers of exposed subjects and may be spurious owing to the problem of multiple comparisons.
开展了一项针对26例肾癌死亡病例的厂内病例对照研究，以确定在一家多工序化学品生产工厂的部分员工样本中观察到的该疾病死亡率明显上升是否可能与职业暴露有关。未发现能够解释这一超额死亡率的因素。在氯气生产的电解槽维护区域工作以及接触该工作中假定存在的石棉和苛性碱（而非氯气）的员工，其比值比升高。虽然此前曾报道过肾癌与石棉之间存在关联，但苛性碱本身与肾癌的关联并不符合其他人先前的观察结果。在镁生产岗位工作以及在此过程中接触二氧化硫和热的员工，其风险估计值降低。风险增加和降低的情况虽然在统计学上具有显著性，但均基于少量暴露对象，可能因多重比较问题而存在虚假性。
