Hancock B G, Black C D
Am J Hosp Pharm. 1985 Feb;42(2):335-9.
Delivery of diazepam through a polyethylene-lined i.v. administration set and through a polyvinyl chloride (PVC) set was compared. Diazepam was prepared in concentrations of 50 mg/500 mL and 100 mg/500 mL in 0.9% sodium chloride injection and 5% dextrose injection in glass containers. Diazepam concentrations were measured by high-performance liquid chromatography at 0 through 5 hours in samples collected simultaneously from the glass solution containers and from the distal ends of a PVC administration set and a polyethylene-lined (non-PVC) set. Flow rates of 50 and 100 mL/hr were tested. For the non-PVC sets, diazepam concentration in the infusate was not significantly different from concentration in the glass container at any sampling time. The overall percentage of diazepam recovered was 100.7 +/- 6.8%. For the PVC sets, diazepam concentration in the infusate was less than in the container at all sampling times, and the overall percentage of diazepam recovered was 65.4 +/- 13.3% (significantly different from delivery for the non-PVC sets). Delivery through the non-PVC sets was not affected by flow rate, type of solution, or concentration of diazepam. For infusion periods of up to five hours, delivery of diazepam through polyethylene-lined i.v. administration sets was superior to delivery through polyvinyl chloride sets.
比较了地西泮通过内衬聚乙烯的静脉输液器和聚氯乙烯（PVC）输液器的输注情况。地西泮分别以50mg/500mL和100mg/500mL的浓度溶于玻璃容器中的0.9%氯化钠注射液和5%葡萄糖注射液中。通过高效液相色谱法在0至5小时内，对同时从玻璃溶液容器、PVC输液器远端和内衬聚乙烯（非PVC）输液器远端采集的样本中的地西泮浓度进行了测定。测试了50和100mL/小时的流速。对于非PVC输液器，在任何采样时间，输注液中的地西泮浓度与玻璃容器中的浓度无显著差异。地西泮的总体回收率为100.7±6.8%。对于PVC输液器，在所有采样时间，输注液中的地西泮浓度均低于容器中的浓度，地西泮的总体回收率为65.4±13.3%（与非PVC输液器的输注情况有显著差异）。通过非PVC输液器的输注不受流速、溶液类型或地西泮浓度的影响。在长达五小时的输注期间，地西泮通过内衬聚乙烯的静脉输液器的输注效果优于通过聚氯乙烯输液器的输注效果。
