Buzejic Matija, Bukumiric Zoran, Rovcanin Branislav, Jovanovic Milan, Stojanovic Marina, Zoric Goran, Tausanovic Katarina, Slijepcevic Nikola, Zivaljevic Vladan
Clinic for Endocrine Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Institute of Medical Statistics and Informatics, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Diagnostics (Basel). 2024 Dec 14;14(24):2817. doi: 10.3390/diagnostics14242817.
Follicular thyroid carcinoma (FTC) is categorized into three groups: minimally invasive FTC (MIFTC), encapsulated angioinvasive FTC (EAIFTC), and widely invasive FTC (WIFTC). FTC is the second most common type of thyroid tumor, though it remains relatively rare in the general population. This study aimed to examine the prognosis and prognostic factors in patients with follicular thyroid carcinoma.
Data were obtained from a tertiary referral center for 130 FTC patients, covering the period from 1995 to 2020. Clinical data included demographic characteristics, tumor features, type of surgery, tumor recurrence, and vital status. Descriptive statistical methods, Kaplan-Meier survival curves, and Cox proportional hazard regression were used for statistical analysis to identify independent predictors.
Distant metastases occurred in 12 patients during the follow-up period. The 5-year, 10-year, 15-year, and 20-year cancer-specific survival (CSS) rates were 98.1%, 92.3%, 83.5%, and 79.8%, respectively. Independent unfavorable prognostic factors for CSS included widely invasive tumor type (hazard ratio [HR] 3.63, 95% CI 1.29-10.18), multifocality (HR 6.7, 95% CI 1.37-32.72), and presence of distant metastases (HR 2.29, 95% CI 1.08-4.84). When disease-free interval (DFI) was considered, the 5-year, 10-year, 15-year, and 20-year rates were 92.3%, 85.3%, 82.0%, and 76.6%, respectively. Independent unfavorable prognostic factors for DFI were widely invasive tumor type (HR 2.53, 95% CI 1.02-6.28) and tumor multifocality (HR 7.69, 95% CI 1.07-55.17).
The 10-year survival rate for patients with FTC is relatively favorable. Factors associated with poorer prognosis include the presence of distant metastases, WIFTC, and multifocality. Factors linked to disease recurrence are WIFTC and multifocality.
滤泡性甲状腺癌（FTC）分为三组：微小浸润性FTC（MIFTC）、包膜血管浸润性FTC（EAIFTC）和广泛浸润性FTC（WIFTC）。FTC是第二常见的甲状腺肿瘤类型，不过在普通人群中仍然相对罕见。本研究旨在探讨滤泡性甲状腺癌患者的预后及预后因素。
数据来自一家三级转诊中心的130例FTC患者，涵盖1995年至2020年期间。临床数据包括人口统计学特征、肿瘤特征、手术类型、肿瘤复发和生存状态。采用描述性统计方法、Kaplan-Meier生存曲线和Cox比例风险回归进行统计分析，以确定独立预测因素。
随访期间12例患者发生远处转移。5年、10年、15年和20年的癌症特异性生存率（CSS）分别为98.1%、92.3%、83.5%和79.8%。CSS的独立不良预后因素包括广泛浸润性肿瘤类型（风险比[HR] 3. six3，95%置信区间1.29 - 10.18）、多灶性（HR 6.7，95%置信区间1.37 - 32.72）和远处转移的存在（HR 2.29，95%置信区间1.08 - 4.84）。当考虑无病生存期（DFI）时，5年、10年、15年和20年的比率分别为92.3%、85.3%、82.0%和76.6%。DFI的独立不良预后因素为广泛浸润性肿瘤类型（HR 2.53，95%置信区间1.02 - 6.28）和肿瘤多灶性（HR 7.69，95%置信区间1.07 - 55.17）。
FTC患者的10年生存率相对良好。与较差预后相关的因素包括远处转移的存在、WIFTC和多灶性。与疾病复发相关的因素是WIFTC和多灶性。
