Sadovnick A D, Baird P A
Am J Med Genet. 1985 Feb;20(2):349-54. doi: 10.1002/ajmg.1320200218.
The diagnosis of multiple sclerosis (MS) is frequently made during the reproductive years, and there is increasing evidence that it has a genetic causal component. An increasing number of couples are concerned about recurrence and they request reproductive counselling at genetic clinics or from their physicians. Here we outline factors to be considered in the reproductive counselling of such individuals. These include empiric recurrence risks, the effect of pregnancy and delivery on maternal MS, overall pregnancy outcome, longterm prognosis for the affected parent, and the possibility of sexual dysfunction in couples trying to conceive a child.
多发性硬化症（MS）的诊断通常在育龄期做出，并且越来越多的证据表明它有遗传因果成分。越来越多的夫妇担心疾病复发，他们在基因诊所或向医生寻求生殖咨询。在此，我们概述了在此类个体的生殖咨询中需要考虑的因素。这些因素包括经验性复发风险、妊娠和分娩对母体MS的影响、整体妊娠结局、患病父母的长期预后，以及尝试受孕的夫妇出现性功能障碍的可能性。
