Kozłowski Mateusz, Borzyszkowska Dominika, Golara Anna, Durys Damian, Piotrowska Katarzyna, Kempińska-Podhorodecka Agnieszka, Cymbaluk-Płoska Aneta
Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Biomedicines. 2024 Nov 21;12(12):2652. doi: 10.3390/biomedicines12122652.
Ovarian cancer is one of the most common cancers in women. Markers associated with ovarian cancer are still being sought. The aim of this study was to evaluate the expression of BRIP-1 (FANCJ) and FANCI proteins in ovarian cancer tissue and to assess these expressions in differentiating the described clinical features. The study enrolled 68 patients with ovarian cancer. The cohort was divided into a HGSOC (high-grade serous ovarian cancer) group and a non-HGSOC group, which represented ovarian cancer other than HGSOC. Immunohistochemical evaluation of FANCI and BRIP-1 (FANCJ) protein expression in ovarian cancer tissue samples was performed. All statistical analyses were performed using StatView software (Carry, NC, USA). The FANCI protein mostly showed moderate positive and strong positive expression, while BRIP-1 protein mostly showed no expression or positive expression. Patients with lower expression of FANCI and BRIP-1 showed differences in the clinical stage of HGSOC, which was not observed in patients with higher expression of these proteins. In addition, patients with lower BRIP-1 expression showed differences in menopausal status, which was not observed in patients with higher expression of this protein. This study shows that FANCI protein is a marker associated with lower FIGO stage and histologically high-grade cancer in a group of all ovarian cancers and in non-HGSOC.
卵巢癌是女性最常见的癌症之一。与卵巢癌相关的标志物仍在探寻中。本研究的目的是评估BRIP-1（FANCJ）和FANCI蛋白在卵巢癌组织中的表达，并评估这些表达在区分所述临床特征方面的作用。该研究纳入了68例卵巢癌患者。该队列被分为高级别浆液性卵巢癌（HGSOC）组和非HGSOC组，后者代表除HGSOC以外的卵巢癌。对卵巢癌组织样本中的FANCI和BRIP-1（FANCJ）蛋白表达进行了免疫组织化学评估。所有统计分析均使用StatView软件（美国北卡罗来纳州卡里）进行。FANCI蛋白大多呈中度阳性和强阳性表达，而BRIP-1蛋白大多呈无表达或阳性表达。FANCI和BRIP-1表达较低的患者在HGSOC的临床分期上存在差异，而这些蛋白表达较高的患者未观察到这种差异。此外，BRIP-1表达较低的患者在绝经状态上存在差异，而该蛋白表达较高的患者未观察到这种差异。本研究表明，在所有卵巢癌组和非HGSOC组中，FANCI蛋白是与较低的国际妇产科联盟（FIGO）分期和组织学高级别癌症相关的标志物。
