Yemini M, Borenstein R, Dreazen E, Apelman Z, Mogilner B M, Kessler I, Lancet M
Am J Obstet Gynecol. 1985 Mar 1;151(5):574-7. doi: 10.1016/0002-9378(85)90141-3.
Eighty pregnant women at high risk of giving birth prematurely were divided randomly into two groups. Treatment with either 17 alpha-hydroxyprogesterone caproate, 250 mg by intramuscular injection once a week, or a placebo was given in a double-blind fashion. Imminent premature labor occurred in 29.0% of the treated group and in 59.4% of the control group (p less than 0.025). The rate of premature deliveries was also significantly lower in the treated group (16.1%) than in the control group (37.82%) (p less than 0.05). There were no cases of perinatal death or fetal malformations in either group. The mean birth weight of all infants of the treated group was significantly higher than in those of the control group (3111.9 +/- 905 gm versus 2680 +/- 813.4 gm, p less than 0.05). The results support treatment with progesterone caproate for the prevention of premature labor.
80名有早产高风险的孕妇被随机分为两组。一组采用己酸17α-羟孕酮治疗，每周一次肌肉注射250毫克，另一组给予安慰剂，采用双盲方式。治疗组即将发生早产的比例为29.0%，对照组为59.4%（p<0.025）。治疗组的早产率（16.1%）也显著低于对照组（37.82%）（p<0.05）。两组均无围产期死亡或胎儿畸形病例。治疗组所有婴儿的平均出生体重显著高于对照组（分别为3111.9±905克和2680±813.4克，p<0.05）。结果支持己酸孕酮用于预防早产的治疗。
