Taguchi O, Nishizuka Y
Am J Obstet Gynecol. 1985 Mar 1;151(5):675-8. doi: 10.1016/0002-9378(85)90163-2.
Immature female mice of the NMRI strain were treated with 20 micrograms/day of tamoxifen or vehicle for the first 3 days after birth. At 90 days of age, vaginas, uteri, and ovaries were examined histologically. A benign epithelial change, vaginal adenosis characterized by abnormal growth of columnar epithelium with glandular structures, was found in all of the tamoxifen-treated mice. Anatomic anomalies such as hypospadias, cervical hypoplasia, uterine hypoplasia, and absence of corpora lutea also were commonly observed. Such abnormalities were not found in the control mice.
出生后的头3天，用他莫昔芬（每天20微克）或赋形剂处理NMRI品系的未成年雌性小鼠。在90日龄时，对阴道、子宫和卵巢进行组织学检查。在所有接受他莫昔芬治疗的小鼠中均发现了一种良性上皮变化，即阴道腺病，其特征为具有腺结构的柱状上皮异常生长。还普遍观察到诸如尿道下裂、宫颈发育不全、子宫发育不全和黄体缺失等解剖学异常。在对照小鼠中未发现此类异常。
