Chamberlain P F, Cumming M, Torchia M G, Biehl D, Manning F A
Am J Obstet Gynecol. 1985 Mar 15;151(6):815-9. doi: 10.1016/0002-9378(85)90527-7.
The response of the ovine fetus to maternal furosemide administration was studied in six chronically catheterized fetal lamb preparations. These studies indicate that in the chronic sheep model maternally administered diuretics do not augment fetal urine production. Additionally, passage of the drug from the maternal intravascular compartment to the fetal intravascular compartment could not be demonstrated. It is suggested that on the basis of these data, the results of the "Lasix challenge test" should be interpreted with caution when they are used to evaluate human fetal renal function.
在六个长期插管的胎羊标本中研究了绵羊胎儿对母体给予速尿的反应。这些研究表明，在慢性绵羊模型中，母体给予利尿剂不会增加胎儿尿量。此外，未证明药物能从母体血管腔进入胎儿血管腔。基于这些数据，建议在使用“速尿激发试验”结果评估人类胎儿肾功能时应谨慎解释。
