Berson E L, Sandberg M A, Rosner B, Birch D G, Hanson A H
Am J Ophthalmol. 1985 Mar 15;99(3):240-51. doi: 10.1016/0002-9394(85)90351-4.
Ninety-four patients, 6 to 49 years old, with progressive forms of retinitis pigmentosa were examined at baseline and annually for three consecutive years with respect to visual acuity, kinetic visual fields, dark-adaptation thresholds, computer-averaged electroretinograms, and fundus photographs. A subset was recalled within two months of a given visit to measure intervisit variability and to develop criteria for what constitutes significant (P less than .01) functional change. Over a three-year interval full-field electroretinograms declined significantly in 66 of 86 patients (77%) with detectable responses at baseline. Patients lost an average of 16% to 18.5% of remaining electroretinographic amplitude per year and 4.6% of remaining visual field area per year. Bone spicule pigmentation increased in 41 of 76 patients for whom we could make comparisons over a three-year interval (54%). Visual acuity and dark-adaptation thresholds remained relatively stable.
94名年龄在6至49岁之间、患有进行性视网膜色素变性的患者在基线时接受了检查，并连续三年每年进行检查，内容包括视力、动态视野、暗适应阈值、计算机平均视网膜电图和眼底照片。在每次就诊后的两个月内召回一部分患者，以测量就诊期间的变异性，并制定构成显著（P小于0.01）功能变化的标准。在三年的时间间隔内，86名基线时有可检测反应的患者中，有66名（77%）的全视野视网膜电图显著下降。患者每年平均损失剩余视网膜电图振幅的16%至18.5%，以及每年剩余视野面积的4.6%。在76名我们能够在三年时间间隔内进行比较的患者中，有41名（54%）骨针状色素沉着增加。视力和暗适应阈值保持相对稳定。
