Glasser D B, Gardner S, Ellis J G, Pettit T H
Am J Ophthalmol. 1985 Mar 15;99(3):329-32. doi: 10.1016/0002-9394(85)90364-2.
Loading doses and extended dosing intervals were studied in a rabbit model using topically applied gentamicin in a concentration of 13.6 mg/ml. Loading doses consisting of one drop every minute for five minutes produced significantly higher gentamicin concentrations in the cornea during the early hours of treatment than regimens using one drop every hour and one drop every 30 minutes. Extended dosing intervals of two and four hours, when used in conjunction with an initial loading dose, produced peak gentamicin levels above 125 micrograms/g of cornea. However, trough levels with these extended dosing intervals were significantly lower than troughs during hourly gentamicin administration. An extended dosing interval regimen consisting of three drops every two hours maintained peak and trough levels equal to those produced by one drop an hour.
在兔模型中，使用浓度为13.6毫克/毫升的局部应用庆大霉素研究了负荷剂量和延长给药间隔。在治疗早期，每5分钟滴一滴，共滴5分钟的负荷剂量在角膜中产生的庆大霉素浓度明显高于每小时滴一滴和每30分钟滴一滴的给药方案。当与初始负荷剂量联合使用时，两小时和四小时的延长给药间隔产生的庆大霉素峰值水平高于125微克/克角膜。然而，这些延长给药间隔的谷值水平明显低于每小时给予庆大霉素时的谷值。每两小时滴三滴的延长给药间隔方案维持的峰值和谷值水平与每小时滴一滴时产生的水平相当。
