细胞疗法作为提高造血干细胞移植疗效的一种方法。
Cell Therapy as a Way to Increase the Effectiveness of Hematopoietic Stem Cell Transplantation.
作者信息
Pashkina Ekaterina, Blinova Elena, Bykova Maria, Aktanova Alina, Denisova Vera
机构信息
Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya st., 630099 Novosibirsk, Russia.
Department of Clinical Immunology, Novosibirsk State Medical University, 52, Krasny Prospect, 630091 Novosibirsk, Russia.
出版信息
Cells. 2024 Dec 12;13(24):2056. doi: 10.3390/cells13242056.
Hematopoietic stem cell transplantation (HSCT) is a standard method for treating a number of pathologies, primarily blood diseases. Timely restoration of the immune system after HSCT is a critical factor associated with the development of complications such as relapses or secondary tumors and various infections, as well as the graft-versus-host reaction in allogeneic transplantation, which ultimately affects the survival of patients. Introduction into the recipient's body of immune system cells that are incapable of sensitization by recipient antigens during the period of immune reconstitution can increase the rate of restoration of the immune system, as well as reduce the risk of complications. This review presents the results of studies on cell therapy with various cell subpopulations of both bone marrow and mesenchymal origin during HSCT.
造血干细胞移植（HSCT）是治疗多种疾病（主要是血液疾病）的标准方法。HSCT后免疫系统的及时恢复是一个关键因素，与复发或继发性肿瘤等并发症的发生、各种感染以及异基因移植中的移植物抗宿主反应相关，这些最终都会影响患者的生存。在免疫重建期间将不能被受体抗原致敏的免疫系统细胞引入受体体内，可以提高免疫系统的恢复速度，并降低并发症的风险。本综述介绍了HSCT期间使用骨髓和间充质来源的各种细胞亚群进行细胞治疗的研究结果。
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