Budin Corina Eugenia, Cocuz Iuliu Gabriel, Sabău Adrian-Horațiu, Niculescu Raluca, Cazacu Cristian, Ianoși Edith-Simona, Cotoi Ovidiu Simion
Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Targu Mures, Romania.
Pneumology Department, Mures Clinical County Hospital, 547530 Targu Mures, Romania.
Life (Basel). 2024 Dec 5;14(12):1611. doi: 10.3390/life14121611.
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, with multiple independent risk factors contributing to its development. The objective of this study was represented by the impact of independent risk factors, such as smoking, anemia, cachexia or COPD (chronic obstructive pulmonary disease) for lung cancer development.
We conducted a retrospective study, and we analyzed a database of 412 patients hospitalized between 1 February and 31 December 2023 in the Pulmonology Department of the Mureș County Clinical Hospital. Following the analysis of the inclusion and exclusion criteria, the final analyzed group included 115 patients.
From the study group, 88 patients were diagnosed with non-small cell lung cancer and 27 with small cell lung cancer. Of the non-small cell lung cancer patients, 50% had adenocarcinoma and 50% had squamous cell carcinoma. Chronic obstructive pulmonary disease and cardiovascular diseases predominate as concomitant pathologies, with 82 and 81 cases identified among the patients evaluated, respectively. The incidence of diabetes mellitus was n = 20 for the patients, followed by asthma and other neoplasms. The body mass index was also analyzed with an average of 24.6. Body mass index does not correlate with histological type. The mean hemoglobin value in the group of patients was 12.8, and this could not be correlated with the histopathological type.
Chronic obstructive pulmonary disease and lung cancer may just be two different clinical presentations based on the same etiological factors, which also have a lot of overlapping pathophysiological mechanisms. Therefore, Chronic obstructive pulmonary disease represents an individual risk factor for developing lung cancer. Smoking, as well as anemia, cachexia or other comorbidities (COPD), are individual risk factors for lung cancer.
肺癌仍然是全球癌症相关死亡的主要原因之一，多种独立危险因素导致其发生。本研究的目的是探讨吸烟、贫血、恶病质或慢性阻塞性肺疾病（COPD）等独立危险因素对肺癌发生的影响。
我们进行了一项回顾性研究，分析了2023年2月1日至12月31日在穆列什县临床医院肺病科住院的412例患者的数据库。经过纳入和排除标准分析，最终分析组包括115例患者。
研究组中，88例患者被诊断为非小细胞肺癌，27例为小细胞肺癌。在非小细胞肺癌患者中，50%为腺癌，50%为鳞状细胞癌。慢性阻塞性肺疾病和心血管疾病是主要的伴随疾病，在评估的患者中分别发现82例和81例。糖尿病的发病率为n = 20，其次是哮喘和其他肿瘤。还分析了体重指数，平均为24.6。体重指数与组织学类型无关。患者组的平均血红蛋白值为12.8，这与组织病理学类型无关。
慢性阻塞性肺疾病和肺癌可能只是基于相同病因因素的两种不同临床表现，它们也有许多重叠的病理生理机制。因此，慢性阻塞性肺疾病是发生肺癌的个体危险因素。吸烟以及贫血、恶病质或其他合并症（COPD）都是肺癌的个体危险因素。
