Calva Lopez Andres, Robles Garcia Jose Enrique, Yanez Ruiz Carlos Andres, Tapia Tapia Mario Daniel, Talavera Cobo Vanessa, Muñoz Bastidas Carmina Alejandra, Sanchez Zalabardo Daniel, Miñana Lopez Bernardino
Department of Urology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Life (Basel). 2024 Dec 11;14(12):1647. doi: 10.3390/life14121647.
Chronic kidney disease (CKD) is a prevalent disease affecting almost 10% of the world's population, with many cases progressing to end-stage kidney disease (ESKD). Kidney transplantation (KT) is the gold-standard treatment for ESKD. Due to growing KT waitlists, the deceased kidney donor (DKDs) criteria have expanded to increase the number of available kidney grafts. Kidney graft preservation ensures optimal graft function after KT. Static cold storage (SCS) as a preservation method is still widely used. Hypothermic machine perfusion (HMP) has proven to decrease delayed graft function (DGF) and increase graft survival. Most recent studies advocate for the use of HMP regardless of donor type. However, emerging technologies, such as hypothermic oxygenated machine perfusion (HOPE) and normothermic machine perfusion (NMP), have shown promising results in specific scenarios. This review aims to provide a summary of the well-established kidney graft preservation methods and their outcomes, as well as novel technological advances that allow for newer preservation strategies.
慢性肾脏病（CKD）是一种普遍存在的疾病，影响着全球近10%的人口，许多病例会进展为终末期肾病（ESKD）。肾移植（KT）是ESKD的金标准治疗方法。由于等待肾移植的名单不断增加，已故肾供体（DKD）的标准已经扩大，以增加可用肾移植的数量。肾移植保存可确保肾移植术后的最佳移植功能。静态冷藏（SCS）作为一种保存方法仍被广泛使用。低温机器灌注（HMP）已被证明可减少移植肾功能延迟恢复（DGF）并提高移植存活率。最近的研究主张无论供体类型如何都使用HMP。然而，新兴技术，如低温氧合机器灌注（HOPE）和常温机器灌注（NMP），在特定情况下已显示出有前景的结果。本综述旨在总结成熟的肾移植保存方法及其结果，以及允许采用更新保存策略的新技术进展。
