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老年患者阻塞性睡眠呼吸暂停管理中的挑战

Challenges in Obstructive Sleep Apnea Management in Elderly Patients.

作者信息

Joskin Aude, Bruyneel Marie

机构信息

Department of Pulmonary Medicine, Saint-Pierre University Hospital, Brussels, Belgium and Université Libre de Bruxelles, 1000 Brussels, Belgium.

Department of Pulmonary Medicine, Brugmann University Hospital, Brussels, Belgium and Université Libre de Bruxelles, 1020 Brussels, Belgium.

出版信息

J Clin Med. 2024 Dec 18;13(24):7718. doi: 10.3390/jcm13247718.

Abstract

With the aging of the population, obstructive sleep apnea (OSA) in elderly patients is now more commonly seen in clinical practice. In older people, sleepiness is less marked than in younger patients, but insomnia symptoms are more common. Comorbidities are numerous and related to cardiometabolic and cognitive conditions. Polygraphy can be used to establish the diagnosis in the vast majority of cases, but polysomnography is indicated in cases of comorbid sleep disorders. Continuous positive airway pressure (CPAP) remains the cornerstone of treatment, but compliance decreases with age, especially in those over 80, and when cognitive disorders are also present. In these patients, CPAP can be beneficial in terms of nighttime symptoms, sleepiness, mood, and cognition but can also prevent cardiovascular and cerebrovascular disorders, especially in severeOSA patients. For this reason, we should offer this treatment to elderly patients and devise strategies to support them with treatment difficulties (e.g., therapeutic education, adapted masks, and telemonitoring). In the future, we need prospective studies to help identify elderly patients who will gain the greatest long-term benefit from treatment. Dedicated sleep testing, OSA severity markers, and specific questionnaires need to be developed in this older, but large, OSA population.

摘要

随着人口老龄化,老年患者的阻塞性睡眠呼吸暂停(OSA)在临床实践中现在更为常见。在老年人中,嗜睡不如年轻患者明显,但失眠症状更为常见。合并症众多,且与心脏代谢和认知状况相关。在绝大多数情况下,多导睡眠图可用于确诊,但对于合并睡眠障碍的病例,则需要进行多导睡眠监测。持续气道正压通气(CPAP)仍然是治疗的基石,但依从性会随着年龄增长而降低,尤其是80岁以上的患者,以及同时存在认知障碍的患者。对于这些患者,CPAP在夜间症状、嗜睡、情绪和认知方面可能有益,还可预防心血管和脑血管疾病,尤其是重度OSA患者。因此,我们应该为老年患者提供这种治疗,并制定策略来帮助他们应对治疗困难(如治疗教育、适配面罩和远程监测)。未来,我们需要开展前瞻性研究,以帮助确定哪些老年患者将从治疗中获得最大的长期益处。需要针对这个庞大的老年OSA人群开发专门的睡眠测试、OSA严重程度标志物和特定问卷。

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本文引用的文献

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Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity.替尔泊肽治疗阻塞性睡眠呼吸暂停和肥胖。
N Engl J Med. 2024 Oct 3;391(13):1193-1205. doi: 10.1056/NEJMoa2404881. Epub 2024 Jun 21.
2
Central sleep apnoea: not just one phenotype.中枢性睡眠呼吸暂停:不仅仅是一种表型。
Eur Respir Rev. 2024 Mar 27;33(171). doi: 10.1183/16000617.0141-2023. Print 2024 Jan 31.

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