Hassan Adla B, Almarabheh Amer, Almekhyal Abdulaziz, AlAwadhi Danya Abdulhameed, Jahrami Haitham
College of Medicine and Health Sciences, Arabian Gulf University, Manama 329, Bahrain.
King Abdullah Medical City, Manama 329, Bahrain.
Medicina (Kaunas). 2024 Dec 18;60(12):2078. doi: 10.3390/medicina60122078.
: Compared to the general population, rheumatoid arthritis (RA) patients have additional disease-specific risk factors for osteoporosis that include chronic exposure to systemic inflammation. The current study aimed to investigate the prevalence of osteoporosis and its associated risk factors, such as age, sex, body mass index (BMI), uric acid (UA), and vitamin D status, but also the coexistence of type 2 diabetes mellitus (DMT2) and breast cancer (Ca breast) in patients with RA in Bahrain. : Data from DEXA scans were collected retrospectively from the patient's electronic health records. All patients who had BMD data and at least one single comorbidity, including RA, were included in the current study. The collected data were analyzed by using SPSS, version 28. : A total of 4396 patients were included in the current study. The comorbidities among this cohort were as follows: 3434 patients had endocrinological diseases, among them 63.6% had DMT2; 1870 patients had rheumatological diseases, among them 15.1% had rheumatoid arthritis; and 941 patients had malignancies, among them 75.6% had breast cancer. Our results indicated that patients with RA had a high prevalence of low BMD (72.30%, < 0.001) and low vitamin D levels (63.10%, < 0.001) but high serum UA (20.85%). Comparing RA with non-RA patients, our results showed a statistically significant association between RA and each of BMD and UA ( = 0.017 and = 0.004, respectively), but also between RA and each of age ( = 0.001) and Ca breast ( < 0.001). However, no association was found between RA and BMI, DMT2, or vitamin D status. : RA patients had a high prevalence of low BMD (72.3%) and low vitamin D (63.10%) but high serum UA (20.85%). The risk of osteoporosis, hypovitaminosis, and gout must be kept in mind during the evaluation of any case with RA.
与普通人群相比，类风湿关节炎（RA）患者存在额外的特定疾病骨质疏松风险因素，包括长期暴露于全身炎症。本研究旨在调查巴林RA患者中骨质疏松症的患病率及其相关风险因素，如年龄、性别、体重指数（BMI）、尿酸（UA）和维生素D状态，以及2型糖尿病（DMT2）和乳腺癌（Ca breast）的共存情况。：双能X线吸收法（DEXA）扫描数据是从患者的电子健康记录中回顾性收集的。所有有骨密度（BMD）数据且至少有一种合并症（包括RA）的患者都纳入了本研究。收集的数据使用SPSS 28版进行分析。：本研究共纳入4396例患者。该队列中的合并症如下：3434例患者患有内分泌疾病，其中63.6%患有DMT2；1870例患者患有风湿性疾病，其中15.1%患有类风湿关节炎；941例患者患有恶性肿瘤，其中75.6%患有乳腺癌。我们的结果表明，RA患者低骨密度的患病率很高（72.30%，<0.001），维生素D水平低（63.10%，<0.001），但血清尿酸高（20.85%）。将RA患者与非RA患者进行比较，我们的结果显示RA与骨密度和尿酸之间均存在统计学显著关联（分别为=0.017和=0.004），RA与年龄（=0.001）和乳腺癌（<0.001）之间也存在统计学显著关联。然而，未发现RA与BMI、DMT2或维生素D状态之间存在关联。：RA患者低骨密度的患病率很高（72.3%），维生素D水平低（63.10%），但血清尿酸高（20.85%）。在评估任何RA病例时，必须牢记骨质疏松症、维生素缺乏症和痛风的风险。
