Jiang Lina, Jin Yifei, Li Jingjing, Zhang Rongqiu, Zhang Yidun, Cheng Hongliang, Lu Bing, Zheng Jing, Li Li, Wang Zhongyi
Xiamen Center for Disease Control and Prevention, 681 Shengguang Road, Xiamen 361021, China.
National Key Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, 20 Dongdajie Road, Beijing 100071, China.
Pathogens. 2024 Dec 17;13(12):1113. doi: 10.3390/pathogens13121113.
Respiratory pathogen coinfections pose significant challenges to global public health, particularly regarding the intersecting epidemics of COVID-19 and influenza. This study investigated the incidences of respiratory infectious pathogens in this unique context. We collected throat swab samples from 308 patients with a fever from outpatient and emergency departments at sentinel surveillance hospitals in Xiamen, southeast of China, between April and May 2023, testing for SARS-CoV-2 and 26 other respiratory pathogens. The coinfection rate of the XBB SARS-CoV-2 variant with other respiratory pathogens was higher than that observed during the Alpha and Delta phases. Among patients with influenza, bacterial coinfections were more prevalent. Only 0.65% (2/308) of the patients were concurrently infected with both COVID-19 and influenza. Age-stratified analysis showed a clear pattern, with a higher incidence of coinfections in children under 18 years of age. These findings highlight the need for the timely detection of respiratory pathogen coinfections and for the implementation of appropriate interventions, crucial for reducing disease burden during intersecting respiratory epidemics.
呼吸道病原体合并感染给全球公共卫生带来了重大挑战，尤其是在新冠疫情和流感疫情交织的情况下。本研究调查了在这一独特背景下呼吸道感染病原体的发病率。2023年4月至5月期间，我们从中国东南部厦门的哨点监测医院的门诊和急诊科收集了308例发热患者的咽拭子样本，检测了新型冠状病毒（SARS-CoV-2）和其他26种呼吸道病原体。XBB新型冠状病毒变异株与其他呼吸道病原体的合并感染率高于阿尔法和德尔塔阶段。在流感患者中，细菌合并感染更为普遍。仅0.65%（2/308）的患者同时感染了新冠和流感。年龄分层分析显示出一种明显的模式，18岁以下儿童的合并感染发生率更高。这些发现凸显了及时检测呼吸道病原体合并感染以及实施适当干预措施的必要性，这对于在呼吸道疫情交织期间减轻疾病负担至关重要。
