Avila-Luna Alberto, Verduzco-Mendoza Antonio, Olmos-Hernández Adriana, Cortes-Altamirano José Luis, Alfaro-Rodríguez Alfonso, Arias-Montaño José-Antonio, Bueno-Nava Antonio
División de Neurociencias Básicas, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, SSa, Calzada México-Xochimilco 289, Arenal de Guadalupe, Ciudad de México 14389, Mexico.
Bioterio y Cirugía Experimental, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, SSa, Calzada México-Xochimilco 289, Arenal de Guadalupe, Ciudad de México 14389, Mexico.
Pharmaceuticals (Basel). 2024 Dec 20;17(12):1726. doi: 10.3390/ph17121726.
Parkinson's disease is associated with the loss of more than 40% of dopaminergic neurons in the substantia nigra pars compacta. One of the therapeutic options for restoring striatal dopamine levels is the administration of L-3,4-dihydroxyphenylalanine (L-Dopa). However, Parkinson's disease patients on long-term L-Dopa therapy often experience motor complications, such as dyskinesias. L-Dopa-induced dyskinesias (LIDs) manifest as abnormal involuntary movements and are produced by elevated striatal dopamine levels, which lead to increased activity of the basal ganglia direct striato-nigral pathway. Dopamine D receptors are more than 95% confined to neurons of the direct pathway, where they colocalize with histamine H receptors. There is evidence of functional interactions between D and H receptors, and here we review the consequences of these interactions on LIDs.
帕金森病与黑质致密部超过40%的多巴胺能神经元丧失有关。恢复纹状体多巴胺水平的治疗选择之一是给予L-3,4-二羟基苯丙氨酸（左旋多巴）。然而，长期接受左旋多巴治疗的帕金森病患者经常会出现运动并发症，如运动障碍。左旋多巴诱发的运动障碍（LIDs）表现为异常的不自主运动，由纹状体多巴胺水平升高引起，这会导致基底神经节直接纹状体-黑质通路的活性增加。多巴胺D受体95%以上局限于直接通路的神经元，在那里它们与组胺H受体共定位。有证据表明D受体和H受体之间存在功能相互作用，在此我们综述这些相互作用对LIDs的影响。
