• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抑郁症治疗：A型肉毒杆菌毒素有作用吗？

Depression Treatment: Is There a Role for Botulinum Toxin Type A?

作者信息

Rodríguez-Cerdeira Carmen, Eckhardt Westley

机构信息

Department of University Program for Seniors, University of Vigo, E.E. Industrial Rúa Torrecedeira 86, Vigo Campus, 36201 Vigo, Spain.

Fundación Vithas, Grupo Hospitalario Vithas, 28043 Madrid, Spain.

出版信息

Microorganisms. 2024 Dec 17;12(12):2615. doi: 10.3390/microorganisms12122615.

DOI:10.3390/microorganisms12122615
PMID:39770816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11677039/
Abstract

This study aimed to determine whether botulinum toxin type A injected into the muscles of the upper third of the face has antidepressant effects in patients diagnosed with depression. Studies seeking a relationship between botulinum toxin type A and its antidepressant effects were considered in this review. All studies concluded that the facial expression muscles present positive feedback to the brain and enhance mood states. Botulinum toxin when applied to the corrugator and procerus muscles has an antidepressant effect.

摘要

本研究旨在确定注射到面部上三分之一肌肉中的A型肉毒杆菌毒素对被诊断为抑郁症的患者是否具有抗抑郁作用。本综述考虑了寻求A型肉毒杆菌毒素与其抗抑郁作用之间关系的研究。所有研究均得出结论，面部表情肌肉对大脑存在正反馈并增强情绪状态。当将肉毒杆菌毒素应用于皱眉肌和降眉间肌时具有抗抑郁作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/11677039/633da274cda2/microorganisms-12-02615-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/11677039/f80751db81ac/microorganisms-12-02615-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/11677039/d8a924026d05/microorganisms-12-02615-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/11677039/16a3515a2e9e/microorganisms-12-02615-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/11677039/633da274cda2/microorganisms-12-02615-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/11677039/f80751db81ac/microorganisms-12-02615-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/11677039/d8a924026d05/microorganisms-12-02615-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/11677039/16a3515a2e9e/microorganisms-12-02615-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/11677039/633da274cda2/microorganisms-12-02615-g004.jpg

相似文献

1
Depression Treatment: Is There a Role for Botulinum Toxin Type A?抑郁症治疗：A型肉毒杆菌毒素有作用吗？
Microorganisms. 2024 Dec 17;12(12):2615. doi: 10.3390/microorganisms12122615.
2
Addition of an anesthetic agent to enhance the predictability of the effects of botulinum toxin type A injections: a randomized controlled study.添加麻醉剂以提高A型肉毒杆菌毒素注射效果的可预测性：一项随机对照研究。
Mayo Clin Proc. 2000 Jul;75(7):701-4. doi: 10.4065/75.7.701.
3
Botulinum toxin and the facial feedback hypothesis: can looking better make you feel happier?肉毒杆菌毒素与面部反馈假说：看起来更漂亮会让你感觉更快乐吗？
J Am Acad Dermatol. 2008 Jun;58(6):1061-72. doi: 10.1016/j.jaad.2007.10.649.
4
Mechanism of action of botulinum toxin type A in migraine prevention: a pilot study.A型肉毒杆菌毒素预防偏头痛的作用机制：一项初步研究。
Headache. 2004 Sep;44(8):801-5. doi: 10.1111/j.1526-4610.2004.04148.x.
5
Botulinum Toxin Type-A (BoNT-A) Injections of the Corrugator Muscles for Aesthetics and Depression?A型肉毒杆菌毒素注射皱眉肌用于美容和治疗抑郁症？
Plast Surg Nurs. 2016 Oct/Dec;36(4):167-169. doi: 10.1097/PSN.0000000000000159.
6
Aesthetic implications of depressor supercilii muscle block with botulinum toxin type A.A型肉毒毒素皱眉肌阻滞的美学意义。
J Cosmet Dermatol. 2022 Apr;21(4):1374-1378. doi: 10.1111/jocd.14856. Epub 2022 Feb 25.
7
Botulinum toxin type A as an effective prophylactic treatment in primary headache disorders.A型肉毒杆菌毒素作为原发性头痛疾病的一种有效预防性治疗方法。
Headache. 2003 Sep;43(8):853-60. doi: 10.1046/j.1526-4610.2003.03163.x.
8
Can botulinum toxin improve mood in depressed patients?肉毒杆菌毒素能否改善抑郁患者的情绪？
Expert Rev Neurother. 2012 Sep;12(9):1049-51. doi: 10.1586/ern.12.92.
9
Botulinum Toxin Treatment for Depression: A New Paradigm for Psychiatry.肉毒杆菌毒素治疗抑郁症：精神病学的新模式。
Toxins (Basel). 2023 May 14;15(5):336. doi: 10.3390/toxins15050336.
10
The cosmetic use of botulinum toxin type B in the upper face.肉毒杆菌毒素B型在上半脸的美容用途。
Clin Dermatol. 2004 Jan-Feb;22(1):29-33. doi: 10.1016/j.clindermatol.2003.12.033.

本文引用的文献

1
A novel approach to treating post-stroke depression: administration of Botulinum Toxin A via local facial injection.一种治疗中风后抑郁症的新方法：通过局部面部注射施用A型肉毒杆菌毒素。
Front Neurol. 2024 Jun 18;15:1372547. doi: 10.3389/fneur.2024.1372547. eCollection 2024.
2
Botulinum Toxin Injections for Psychiatric Disorders: A Systematic Review of the Clinical Trial Landscape.肉毒杆菌毒素注射治疗精神障碍：临床试验全景的系统回顾。
Toxins (Basel). 2024 Apr 15;16(4):191. doi: 10.3390/toxins16040191.
3
Major depressive disorder: hypothesis, mechanism, prevention and treatment.
重度抑郁症：假说、机制、预防与治疗。
Signal Transduct Target Ther. 2024 Feb 9;9(1):30. doi: 10.1038/s41392-024-01738-y.
4
Letter to the editor: Botulinum toxin for the management of depression: An updated review of the evidence and meta-analysis.致编辑的信：肉毒杆菌毒素用于抑郁症治疗：证据更新综述与荟萃分析
J Psychiatr Res. 2024 Mar;171:161-162. doi: 10.1016/j.jpsychires.2023.12.002. Epub 2023 Dec 23.
5
Comparative effectiveness of two different doses of botulinum toxin A for the treatment of mild to moderate depression.两种不同剂量的A型肉毒杆菌毒素治疗轻至中度抑郁症的比较疗效
J Affect Disord. 2024 Apr 1;350:824-830. doi: 10.1016/j.jad.2024.01.158. Epub 2024 Jan 19.
6
Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases.脑源性神经营养因子信号通路在应激相关脑部疾病发病机制中的作用。
Front Mol Neurosci. 2023 Sep 14;16:1247422. doi: 10.3389/fnmol.2023.1247422. eCollection 2023.
7
Botulinum Toxin Therapy for Psychiatric Disorders in Clinical Practice: A Retrospective Case Study.肉毒杆菌毒素治疗在临床实践中的精神障碍：回顾性病例研究。
Toxins (Basel). 2023 Jun 7;15(6):385. doi: 10.3390/toxins15060385.
8
Botulinum Toxin Treatment for Depression: A New Paradigm for Psychiatry.肉毒杆菌毒素治疗抑郁症：精神病学的新模式。
Toxins (Basel). 2023 May 14;15(5):336. doi: 10.3390/toxins15050336.
9
Depression roundtable: Is there a role for BoNT?抑郁症圆桌会议：肉毒杆菌毒素是否有作用？
Toxicon. 2023 Jun 15;229:107148. doi: 10.1016/j.toxicon.2023.107148. Epub 2023 May 5.
10
Modulation of amygdala activity for emotional faces due to botulinum toxin type A injections that prevent frowning.由于肉毒毒素 A 注射可预防皱眉，从而调节杏仁核对情绪面孔的活动。
Sci Rep. 2023 Feb 27;13(1):3333. doi: 10.1038/s41598-023-29280-x.