Gong Yajun, Wang Ying, Nong Qiying, Hu Peixia, Li Zhiqiang, Huang Xiangyuan, Zhong Meimei, Li Xinyue, Wu Shaomin, Zeng Fangfang, Zhao Na, Qin Yiru, Liu Suhui, Hong Jiaying, Hu Ligang, Zhang Wangjian, Huang Yongshun
Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China.
School of Public Health, Southern Medical University, Guangzhou 510515, China.
Toxics. 2024 Nov 27;12(12):861. doi: 10.3390/toxics12120861.
Large-scale epidemiological studies on the association of blood lead levels with blood pressure and hypertension prevalence are still limited, particularly among lead-exposed workers. The evidence is even more scarce on the interaction of blood lead levels with occupational variables and ambient air pollution levels. We developed mixed-effect models based on a large group of lead-exposed workers (N = 22,002). The results were also stratified by multiple groupings. Compared to participants with blood lead < 20 μg/L, those with levels > 20 μg/L had a 26-37% higher prevalence of hypertension, as well as a 0.65-13.7 mmHg higher systolic and diastolic blood pressure. Workers exposed to high PM10 levels had a 21-28% higher risk. Workers exposed to high temperatures had a 0.41-2.46 mmHg greater increase in blood pressure, and those not exposed to dust had a 1.29-1.65 mmHg greater blood pressure increase. Our findings suggested the negative impact of blood lead on blood pressure and the prevalence of hypertension, with workers exposed to high PM10 concentrations, those exposed to occupational high temperature, and those without dust exposure being more vulnerable.
关于血铅水平与血压及高血压患病率之间关联的大规模流行病学研究仍然有限，尤其是在铅暴露工人中。关于血铅水平与职业变量及环境空气污染水平之间相互作用的证据更为稀少。我们基于一大群铅暴露工人（N = 22,002）建立了混合效应模型。结果也按多种分组进行了分层。与血铅水平<20μg/L的参与者相比，血铅水平>20μg/L的参与者高血压患病率高26 - 37%，收缩压和舒张压也分别高0.65 - 13.7mmHg。暴露于高PM10水平的工人风险高21 - 28%。暴露于高温环境的工人血压升高幅度大0.41 - 2.46mmHg，未暴露于粉尘的工人血压升高幅度大1.29 - 1.65mmHg。我们的研究结果表明血铅对血压和高血压患病率有负面影响，暴露于高PM10浓度、职业高温环境以及未暴露于粉尘的工人更为脆弱。
