Mayan Medicinal Plants and Demonstrate Anti-Infective Properties Against the Priority Antibiotic-Resistant Bacteria and .

(1) Background: Carbapenem-resistant (CBRAB) and (CBRPA) are critical and high-priority pathogens that require new therapeutic developments. Medicinal plants are valuable pharmaceutical resources. This study explored the anti-infective properties of Mayan plants, , and . (2) Methods: Plant parts were extracted using -hexane, and their ability to inhibit bacterial growth and counteract resistance mechanisms and virulence factors in CBRAB and CBRPA was assessed. GC-MS analysis of the composition of the non-polar extracts and chemometric techniques correlated the phytoconstituents with anti-infective properties. (3) Results: liana and flower extracts exhibited potent antibacterial activity against strains (MIC 15.7 to 250 µg/mL) and moderate activity against strains (MIC 250 to 1000 µg/mL). leaf extract at 1000 µg/mL reduced imipenem MIC by 2048-fold for CBRAB, and flower extract significantly inhibited catalase activity (at 62.5 µg/mL) and reduced pyocyanin production (at 1000 µg/mL). Chemometric analysis identified fatty acids, fatty acid amides, terpenes, and higher alkanes as contributors to their anti-infective properties. (4) Conclusions: This study highlights the potential of medicinal plants in the development of novel anti-infective therapies against CBRAB and CBRPA with various targets.