De Monchy J G, Kauffman H F, Venge P, Koëter G H, Jansen H M, Sluiter H J, De Vries K
Am Rev Respir Dis. 1985 Mar;131(3):373-6. doi: 10.1164/arrd.1985.131.3.373.
In order to obtain information about the nature of the local inflammatory process during late asthmatic reactions after house dust mite inhalation, bronchoalveolar lavage (BAL) was performed in 19 asthmatic patients and in 5 control subjects. In 16 of the patients and in all of the control subjects, BAL was performed 6 to 7 h after allergen inhalation. Six of the patients showed early and late asthmatic reactions (LAR), 5 showed early reactions, and 5 showed no reactions. Bronchoalveolar lavage was also performed shortly after the early reaction in 5 patients with documented combined early and late reactions. In the BAL fluid of the patients with LAR, a significant eosinophilia (0.01 less than p less than 0.05) was found compared with that in all other patient groups and with that in the control subjects. This bronchoalveolar eosinophilia was accompanied by elevated eosinophil cationic protein/albumin ratio in the BAL fluid (0.01 less than p less than 0.05). These observations suggest that eosinophils and their mediators might be involved in the development of LAR after allergen inhalation.
为了获取有关吸入屋尘螨后迟发性哮喘反应期间局部炎症过程本质的信息，对19名哮喘患者和5名对照受试者进行了支气管肺泡灌洗（BAL）。在16名患者和所有对照受试者中，在吸入变应原后6至7小时进行了BAL。6名患者出现了早发和迟发性哮喘反应（LAR），5名患者出现了早发反应，5名患者未出现反应。对5名记录有早发和迟发性联合反应的患者，在早发反应后不久也进行了支气管肺泡灌洗。与所有其他患者组及对照受试者相比，LAR患者的BAL液中出现了显著的嗜酸性粒细胞增多（0.01＜p＜0.05）。这种支气管肺泡嗜酸性粒细胞增多伴随着BAL液中嗜酸性粒细胞阳离子蛋白/白蛋白比值升高（0.01＜p＜0.05）。这些观察结果提示，嗜酸性粒细胞及其介质可能参与了吸入变应原后LAR的发生。
