Xiang Chao, Cen Yu-Ke, Yi Ya-Ling, Zhang Lu-Lu, Xue Ya-Ping, Zheng Yu-Guo
Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Engineering Research Center of Bioconversion and Biopurification of Ministry of Education, Zhejiang University of Technology, Hangzhou 310014, China.
J Agric Food Chem. 2025 Jan 22;73(3):1757-1774. doi: 10.1021/acs.jafc.4c07024. Epub 2025 Jan 8.
Avermectins (AVMs) and their derivatives are the most effective and widely used nematicides, insecticides, and acaricides against endo- and ectoparasites of plants, animals, and humans. Demand for avermectins and their highly effective derivatives has increased due to their high cost-effectiveness and wide range of applications as medicines and crop protection products. Due to the unique structures of these compounds and for industrial production purposes, numerous efforts and strategies have been dedicated to enhancing the production of avermectins and creating new analogues in recent years. Here, we have systemically reviewed the recent studies on the biosynthesis and application of avermectins and their derivatives, including avermectin metabolism and its related bioregulation in , approaches for enhancing the bioproduction of avermectins, the structure and toxicology of avermectin derivatives, and future prospects, with a focus on the recent advances in biosynthesis and significance of the superior avermectin derivatives.
阿维菌素（AVMs）及其衍生物是针对植物、动物和人类体内外寄生虫最有效且应用最广泛的杀线虫剂、杀虫剂和杀螨剂。由于阿维菌素及其高效衍生物具有高性价比以及作为药品和作物保护产品的广泛应用范围，对它们的需求不断增加。由于这些化合物的独特结构以及工业生产目的，近年来人们付出了诸多努力并采取了多种策略来提高阿维菌素的产量并创造新的类似物。在此，我们系统回顾了关于阿维菌素及其衍生物的生物合成与应用的最新研究，包括阿维菌素代谢及其在……中的相关生物调节、提高阿维菌素生物产量的方法、阿维菌素衍生物的结构与毒理学以及未来前景，重点关注生物合成的最新进展和优质阿维菌素衍生物的意义。
