Gao Jie, Pan Li, Li Pengxiang, Liu Jing, Yang Ziye, Yang Shushuai, Han Bin, Liu Ping, Wang Can, Chen Liqun, Qu Guangbo, Jiang Guibin
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin 300072, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Environ Sci Technol. 2025 Jan 21;59(2):1133-1144. doi: 10.1021/acs.est.4c09497. Epub 2025 Jan 7.
Airborne exists widely in the natural environment and is closely related to human health. Growing evidence indicates that environmental air pollution elevates the risk of depressive disorders. However, the potential role of airborne in the development of depression remains unclear. This study aims to elucidate the neurotoxic effects and potential mechanisms associated with depression caused by airborne . Mice were randomly divided into four groups, and the experimental groups with environmental were at 4.89 × 10, 8.89 × 10, and 1.27 × 10 CFU/m during four consecutive weeks. Airborne exposure contributed to depression-like behaviors in mice, especially in the high-concentration group. The electroencephalography signal analysis identified uncoupling of theta and gamma bands and a shift of the beta rhythm toward delta oscillation in the medial prefrontal cortex of mice. Neuropathological analysis showed uplifted neuroinflammation and elevated levels of oxidative stress in the brain. Neuroinflammation and oxidative stress resulted in mitochondrial dysfunction, which could lead to apoptosis. Together, this study provides a strong basis for understanding the adverse outcomes of airborne on mental health disorders.
空气中的微生物广泛存在于自然环境中，且与人类健康密切相关。越来越多的证据表明，环境空气污染会增加患抑郁症的风险。然而，空气中的微生物在抑郁症发生过程中的潜在作用仍不清楚。本研究旨在阐明空气中的微生物导致抑郁症的神经毒性作用及潜在机制。将小鼠随机分为四组，连续四周对实验组进行环境微生物暴露，浓度分别为4.89×10、8.89×10和1.27×10 CFU/m。暴露于空气中的微生物会导致小鼠出现类似抑郁的行为，尤其是在高浓度组。脑电图信号分析发现，小鼠内侧前额叶皮质中θ波和γ波解耦，β节律向δ振荡偏移。神经病理学分析显示，大脑中的神经炎症增加，氧化应激水平升高。神经炎症和氧化应激导致线粒体功能障碍，进而可能导致细胞凋亡。总之，本研究为理解空气中的微生物对精神健康障碍的不良影响提供了有力依据。
