Pereira Isabel Ladeira, Hartwig Daiane Drawanz
Laboratory of Bacteriology and Bioassays, Federal University of Pelotas, Pelotas, Brazil.
Infect Immun. 2025 Feb 18;93(2):e0034824. doi: 10.1128/iai.00348-24. Epub 2025 Jan 8.
Combating multidrug-resistant is considered a priority by the World Health Organization. Virulence mechanisms, such as biofilm formation, multidrug resistance, and high adherence to both biotic and abiotic surfaces, underscore the urgency of exploring approaches to control this pathogen. The search for new antibiotic compounds and alternative strategies like immunotherapies and vaccination offers potential solutions to address this pressing health concern. In this context, adhesins play a crucial role in the pathogenicity and virulence of , making them potential targets for therapeutic interventions. To address this, we conducted a systematic review of adhesin research from the last decade (2013-2023). We reviewed 24 papers: 6 utilizing reverse vaccinology bioinformatic tools to predict adhesin targets for vaccine construction, 17 employing DNA recombinant techniques for active and passive immunization or antibody-mediated therapy assays, and 1 paper exploring the impact of pyrogallol therapy on virulence mechanisms. Our review identified over 20 potential targets with significant findings. We screened and summarized these targets to aid in further exploration of therapies and prevention.
对抗多重耐药性被世界卫生组织视为一项优先事项。毒力机制，如生物膜形成、多重耐药性以及对生物和非生物表面的高度粘附，凸显了探索控制这种病原体方法的紧迫性。寻找新的抗生素化合物以及免疫疗法和疫苗接种等替代策略为解决这一紧迫的健康问题提供了潜在的解决方案。在这种背景下，粘附素在[病原体名称]的致病性和毒力中起着关键作用，使其成为治疗干预的潜在靶点。为了解决这一问题，我们对过去十年（2013 - 2023年）关于[病原体名称]粘附素的研究进行了系统综述。我们审查了24篇论文：6篇利用反向疫苗学信息工具预测用于疫苗构建的粘附素靶点，17篇采用DNA重组技术进行[病原体名称]的主动和被动免疫或[病原体名称]抗体介导的治疗分析，还有1篇探讨了连苯三酚疗法对[病原体名称]毒力机制的影响。我们的综述确定了20多个具有重要发现的潜在靶点。我们对这些靶点进行了筛选和总结，以帮助进一步探索治疗方法和预防措施。
