• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

BK通道介导新生海马体中代谢型谷氨酸受体依赖性长时程抑制（mGluR-LTD）的一种突触前形式。

BK channels mediate a presynaptic form of mGluR-LTD in the neonatal hippocampus.

作者信息

Ancatén-González Carlos, Meza Rodrigo C, Gonzalez-Sanabria Naileth, Segura Ignacio, Alcaino Alejandro, Peña-Pichicoi Antonio, Latorre Ramón, Chiu Chiayu Q, Chávez Andrés E

机构信息

Programa de Doctorado en Ciencias Mención Neurociencia, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.

Instituto de Neurociencias, Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.

出版信息

Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2411506122. doi: 10.1073/pnas.2411506122. Epub 2025 Jan 8.

DOI:10.1073/pnas.2411506122
PMID:39773031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11745352/
Abstract

BK channels can control neuronal function, but their functional relevance in activity-dependent changes of synaptic function remains elusive. Here, we report that repetitive low-frequency stimulation activates BK channels through 12(S)HPETE, an arachidonic acid metabolite, produced downstream of postsynaptic metabotropic glutamate receptors (mGluRs) to trigger long-term depression (LTD) at CA3-CA1 synapses in hippocampal slices from P7-P10 mice. Activation of BK channels is subunit specific, as paxilline but not iberiotoxin blocked mGluR-LTD. Also, 12(S)HPETE does not change the electrophysiological properties of the BK channel when the BKα subunit is expressed alone but increases the channel open probability when the BKα is coexpressed with the β4-subunit. Our findings reveal an interaction between 12(S)HPETE and BK channels to regulate synaptic strength at central synapses and increase our understanding of the mechanisms underlying mGluR-LTD in the neonatal hippocampus that likely contribute to circuit maturation necessary for learning.

摘要

BK通道可控制神经元功能，但其在突触功能的活动依赖性变化中的功能相关性仍不清楚。在此，我们报告重复低频刺激通过12(S)HPETE激活BK通道，12(S)HPETE是一种花生四烯酸代谢产物，在突触后代谢型谷氨酸受体(mGluRs)下游产生，以触发P7 - P10小鼠海马切片中CA3 - CA1突触处的长时程抑制(LTD)。BK通道的激活具有亚基特异性，因为蜂毒明肽而非iberiotoxin可阻断mGluR - LTD。此外，当单独表达BKα亚基时，12(S)HPETE不会改变BK通道的电生理特性，但当BKα与β4亚基共表达时，会增加通道开放概率。我们的研究结果揭示了12(S)HPETE与BK通道之间的相互作用，以调节中枢突触的突触强度，并增进了我们对新生海马体中mGluR - LTD潜在机制的理解，这可能有助于学习所需的神经回路成熟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6930/11745352/98805aced8fa/pnas.2411506122fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6930/11745352/e4541189d07b/pnas.2411506122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6930/11745352/28a0e2c847fa/pnas.2411506122fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6930/11745352/c330bae40f88/pnas.2411506122fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6930/11745352/98805aced8fa/pnas.2411506122fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6930/11745352/e4541189d07b/pnas.2411506122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6930/11745352/28a0e2c847fa/pnas.2411506122fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6930/11745352/c330bae40f88/pnas.2411506122fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6930/11745352/98805aced8fa/pnas.2411506122fig04.jpg

相似文献

1
BK channels mediate a presynaptic form of mGluR-LTD in the neonatal hippocampus.BK通道介导新生海马体中代谢型谷氨酸受体依赖性长时程抑制（mGluR-LTD）的一种突触前形式。
Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2411506122. doi: 10.1073/pnas.2411506122. Epub 2025 Jan 8.
2
Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.内源性大麻素介导的海马锥体神经元和 GABA 能中间神经元传入兴奋性突触的长时程抑制。
J Neurosci. 2012 Oct 10;32(41):14448-63. doi: 10.1523/JNEUROSCI.1676-12.2012.
3
12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses.花生四烯酸的12-脂氧合酶代谢产物介导海马CA3-CA1突触处代谢型谷氨酸受体依赖性长时程抑制。
J Neurosci. 2003 Dec 10;23(36):11427-35. doi: 10.1523/JNEUROSCI.23-36-11427.2003.
4
Loss of anoctamin 1 reveals a subtle role for BK channels in lymphatic muscle action potentials.钙激活氯离子通道蛋白 1 缺失揭示 BK 通道在淋巴管平滑肌动作电位中的细微作用。
J Physiol. 2024 Jul;602(14):3351-3373. doi: 10.1113/JP285459. Epub 2024 May 5.
5
Subunit-specific inhibition of BK channels by piperine.胡椒碱对 BK 通道的亚基特异性抑制作用。
Biophys J. 2024 Jul 16;123(14):1942-1953. doi: 10.1016/j.bpj.2023.09.002. Epub 2023 Sep 12.
6
Individual NMDA receptor GluN2 subunit signaling domains differentially regulate the postnatal maturation of hippocampal excitatory synaptic transmission and plasticity but not dendritic morphology.单个N-甲基-D-天冬氨酸受体（NMDA受体）GluN2亚基信号结构域差异性地调节海马兴奋性突触传递和可塑性的出生后成熟，但不影响树突形态。
Synapse. 2024 Jul;78(4):e22292. doi: 10.1002/syn.22292.
7
Alpha-secretase inhibition impairs Group I metabotropic glutamate receptor-mediated protein synthesis, long-term potentiation and long-term depression.α-分泌酶抑制作用损害 I 组代谢型谷氨酸受体介导的蛋白质合成、长时程增强和长时程抑制。
Philos Trans R Soc Lond B Biol Sci. 2024 Jul 29;379(1906):20230481. doi: 10.1098/rstb.2023.0481. Epub 2024 Jun 10.
8
Redox-dependent Cd inhibition of BK-type Ca-activated K channels.氧化还原依赖的 Cd 对 BK 型 Ca 激活的 K 通道的抑制作用。
Biophys J. 2024 Jul 16;123(14):2076-2084. doi: 10.1016/j.bpj.2024.02.015. Epub 2024 Feb 22.
9
Developmental switch in synaptic mechanisms of hippocampal metabotropic glutamate receptor-dependent long-term depression.海马代谢型谷氨酸受体依赖性长时程抑制突触机制中的发育性转变
J Neurosci. 2005 Mar 16;25(11):2992-3001. doi: 10.1523/JNEUROSCI.3652-04.2005.
10
Hippocampal place cell firing patterns can induce long-term synaptic plasticity in vitro.海马体位置细胞的放电模式可在体外诱导长期突触可塑性。
J Neurosci. 2009 May 27;29(21):6840-50. doi: 10.1523/JNEUROSCI.0731-09.2009.

本文引用的文献

1
The small conductance Ca-activated K channel activator GW542573X impairs hippocampal memory in C57BL/6J mice.小电导钙激活钾通道激活剂 GW542573X 损害 C57BL/6J 小鼠的海马记忆。
Neuropharmacology. 2024 Jul 1;252:109960. doi: 10.1016/j.neuropharm.2024.109960. Epub 2024 Apr 16.
2
Ca- and Voltage-Activated K (BK) Channels in the Nervous System: One Gene, a Myriad of Physiological Functions.神经系统中的钙和电压激活钾 (BK) 通道：一个基因，多种生理功能。
Int J Mol Sci. 2023 Feb 8;24(4):3407. doi: 10.3390/ijms24043407.
3
BK potassium currents contribute differently to action potential waveform and firing rate as rat hippocampal neurons mature in the first postnatal week.
BK 钾电流在大鼠海马神经元出生后第一周成熟过程中，对动作电位形态和发放频率的贡献不同。
J Neurophysiol. 2020 Sep 1;124(3):703-714. doi: 10.1152/jn.00711.2019. Epub 2020 Jul 29.
4
Glutamate-activated BK channel complexes formed with NMDA receptors.谷氨酸激活的 BK 通道复合物与 NMDA 受体形成。
Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E9006-E9014. doi: 10.1073/pnas.1802567115. Epub 2018 Sep 4.
5
BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats.BK通道介导大鼠习惯化行为背后的突触可塑性。
J Neurosci. 2017 Apr 26;37(17):4540-4551. doi: 10.1523/JNEUROSCI.3699-16.2017. Epub 2017 Mar 27.
6
LTD-like molecular pathways in developmental synaptic pruning.发育性突触修剪中类似长时程抑制的分子通路。
Nat Neurosci. 2016 Sep 27;19(10):1299-310. doi: 10.1038/nn.4389.
7
BK Channels in the Central Nervous System.中枢神经系统中的BK通道。
Int Rev Neurobiol. 2016;128:281-342. doi: 10.1016/bs.irn.2016.04.001. Epub 2016 May 13.
8
Activity-dependent synaptic plasticity modulates the critical phase of brain development.依赖活动的突触可塑性调节大脑发育的关键阶段。
Brain Dev. 2016 Apr;38(4):355-63. doi: 10.1016/j.braindev.2015.10.008. Epub 2015 Oct 26.
9
TRP channels interaction with lipids and its implications in disease.瞬时受体电位（TRP）通道与脂质的相互作用及其在疾病中的意义。
Biochim Biophys Acta. 2015 Sep;1848(9):1818-27. doi: 10.1016/j.bbamem.2015.03.022. Epub 2015 Mar 30.
10
Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus.齿状回中TRPV1通道对GABA能突触传递的特定区域调节。
J Neurosci. 2014 Dec 10;34(50):16621-9. doi: 10.1523/JNEUROSCI.3635-14.2014.