Dari Mahrokh Abouali Gale, Jaberian Asl Bahar, Dayer Dian, Azizidoost Shirin, Farzaneh Maryam, Salehi Abdolah Mousavi
Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Curr Mol Med. 2025 Jan 3. doi: 10.2174/0115665240345216241120093846.
Ovarian cancer (OC) is a gynecologic disease characterized by the uncontrolled growth and proliferation of abnormal cells in the ovaries, fallopian tubes, or peritoneum. Emerging evidence has shown the pivotal role of non-coding RNAs (ncRNAs), such as miRNAs, in driving the pathogenesis of OC. miRNAs are recognized as small ncRNAs that play critical roles in regulating gene expression in normal development and in disease states, including OC. Among miRNAs, the expression of miR-34a was found to be downregulated in OC. Elevated levels of this miRNA are associated with the induction of apoptosis and the inhibition of OC cell proliferation by targeting various signaling pathways, including NOTCH1, P21/P53, STAT3, and BCL2 in OC. Therefore, miR-34a can be a therapeutic target in the management of OC. In this review, we summarized the functional significance of this miRNA in the treatment of OC.
卵巢癌（OC）是一种妇科疾病，其特征是卵巢、输卵管或腹膜中异常细胞不受控制地生长和增殖。新出现的证据表明，非编码RNA（ncRNA），如微小RNA（miRNA），在驱动OC的发病机制中起关键作用。miRNA被认为是小的ncRNA，在正常发育和包括OC在内的疾病状态下调节基因表达中起关键作用。在miRNA中，发现miR-34a在OC中的表达下调。该miRNA水平升高与通过靶向OC中的各种信号通路（包括NOTCH1、P21/P53、STAT3和BCL2）诱导细胞凋亡和抑制OC细胞增殖有关。因此，miR-34a可以成为OC治疗的靶点。在本综述中，我们总结了这种miRNA在OC治疗中的功能意义。
