Forum Ditte Mathilde Klith, Bjerregaard Camilla, Thomsen Per Hove
Department of Child and Adolescent Psychiatry, Research Unit, Aarhus University Hospital, Psychiatry, Aarhus, Denmark.
Nord J Psychiatry. 2025 Jan;79(1):1-14. doi: 10.1080/08039488.2024.2436987. Epub 2025 Jan 7.
To analyze and interpret why some individuals are resilient to ELS while others are susceptible, resulting in psychiatric outcome later in life, with a focus on the role of DNAm of the gene as a mediating mechanism between ELS and the risk of psychiatric outcomes. We hypothesized that a high level of mental resilience to ELS, expressed as lower incidence of psychiatric outcomes, was associated with attenuated DNAm levels.
The first authors conducted a systematic search on PubMed to identify primary research studies. Abstract were screened and full-text were reviewed to assess the eligibility for inclusion. Consensus on assessment was reached after discussion of eligibility criteria. Studies were sorted based on whether they investigated the association between ELS and DNAm in 1) individuals exposed compared to unexposed to ELS both without a psychiatric outcome or in 2) individuals exposed to ELS with a psychiatric outcome compared to exposed individuals without a psychiatric outcome.
Seven studies met the eligibility criteria. The results were inconsistent; two studies supported our hypothesis, two studies indicated that increased DNAm mediated resilience to ELS, and three studies found no association.
分析并解释为何有些人对早期生活应激（ELS）具有复原力，而另一些人则易受影响，从而导致后期出现精神疾病结局，重点关注该基因的DNA甲基化（DNAm）作为ELS与精神疾病结局风险之间的中介机制所起的作用。我们假设，对ELS具有较高心理复原力（表现为精神疾病结局发生率较低）与DNAm水平减弱有关。
第一作者在PubMed上进行了系统检索，以识别原创性研究。筛选摘要并审阅全文，以评估纳入资格。在讨论纳入标准后就评估达成共识。根据研究是否调查了以下两者之间的关联对研究进行分类：1）未患精神疾病结局的暴露于ELS个体与未暴露个体；2）患有精神疾病结局的暴露于ELS个体与未患精神疾病结局的暴露个体。
七项研究符合纳入标准。结果不一致；两项研究支持我们的假设，两项研究表明DNAm增加介导了对ELS的复原力，三项研究未发现关联。
