Hicks Matthew R, Zwickey Heather, Bradley Ryan
Helfgott Research Institute, National University of Natural Medicine, Portland, OR USA.
J Psychoactive Drugs. 2025 Jan 7:1-7. doi: 10.1080/02791072.2025.2449911.
There are currently no evidence-based treatment guidelines for antisocial personality disorder (ASPD). Instead, treatment typically focuses on comorbid conditions. There is currently no literature documenting cases or research, theoretical or otherwise of using ketamine-assisted therapy or any other psychedelic therapy in cases of ASPD. In this case report, a 43-year-old man seeking ketamine-assisted psychotherapy (KAP) for alcoholism and depression was diagnosed with comorbid antisocial personality disorder. A series of psycholytic (low dose) ketamine therapy sessions and other integrative approaches over the course of 3 years results in resolution of severe alcoholism, reduction in violent thoughts about people and the world, and a reduction in depression symptoms. With additional precautions, utilizing a ketamine-assisted psychotherapy approach led to clinical improvements in depression, alcohol abuse, and ASPD traits.
目前尚无针对反社会人格障碍（ASPD）的循证治疗指南。相反，治疗通常侧重于共病情况。目前没有文献记录在ASPD病例中使用氯胺酮辅助治疗或任何其他迷幻疗法的案例、研究、理论或其他方面。在本病例报告中，一名43岁的男子因酗酒和抑郁症寻求氯胺酮辅助心理治疗（KAP），被诊断为患有共病反社会人格障碍。在3年的时间里，一系列的心理溶解（低剂量）氯胺酮治疗疗程和其他综合方法使严重酗酒问题得到解决，对人和世界的暴力想法减少，抑郁症状减轻。采取额外的预防措施后，采用氯胺酮辅助心理治疗方法使抑郁症、酒精滥用和ASPD特征得到了临床改善。
