Franz T J
Arch Dermatol. 1985 Feb;121(2):203-6.
The percutaneous absorption and excretion of 1% and 5% solutions of minoxidil labeled with carbon 14 were measured in 12 adult male subjects. These subjects were randomly assigned to the 1% and 5% minoxidil testing groups, and all received nine topical applications to a bald area on the scalp, with the radioactive solutions applied on days 1 and 9. Urinary excretion of radioactivity was low, with mean values ranging from 1.6% to 3.9% of applied dose. No radioactivity could be detected in fecal samples. Recovery of radioactivity from the skin surface and from scalp and pillowcase washes was in the range of 41% to 45% of applied dose. No adverse reactions or notable abnormalities were noted in the subjects during the study. Although minoxidil is poorly absorbed through the skin, systemic doses in the range of 2.4 to 5.4 mg/day can be anticipated if application is made to entire scalp.
在12名成年男性受试者中测量了用碳14标记的1%和5%米诺地尔溶液的经皮吸收和排泄情况。这些受试者被随机分配到1%和5%米诺地尔测试组，均在头皮秃发区域进行了9次局部涂抹，放射性溶液分别在第1天和第9天涂抹。放射性物质的尿排泄量较低，平均值为给药剂量的1.6%至3.9%。粪便样本中未检测到放射性。皮肤表面以及头皮和枕套洗涤物中放射性物质的回收率为给药剂量的41%至45%。研究期间，受试者未出现不良反应或明显异常。尽管米诺地尔经皮肤吸收较差，但如果在整个头皮上涂抹，预计全身剂量范围为2.4至5.4毫克/天。
