Mathias C G, Robertson D B
Arch Dermatol. 1985 Feb;121(2):258-61.
Two patients with chronic iridocyclitis had a delayed hypersensitivity reaction, characterized by severe conjunctival inflammation, after retrobulbar injections with a commercial suspension of methylprednisolone acetate. Although patch test reactions to methylprednisolone at enhanced concentrations were negative, delayed hypersensitivity could be easily demonstrated by intradermal testing with this corticosteroid. Both patients also had concomitant delayed hypersensitivity to a proprietary preservative (myristyl gamma-picolinium chloride) in the commercial corticosteroid suspension, which was confirmed by intradermal testing. These observations (negative patch test reactions, positive intradermal test reactions) suggest that the route of administration may be an important determinant of antigenic hapten-protein complex formation and subsequent delayed hypersensitivity responses involving cutaneous or mucocutaneous tissue.
两名患有慢性虹膜睫状体炎的患者在球后注射市售醋酸甲泼尼龙混悬液后出现了以严重结膜炎症为特征的迟发型超敏反应。尽管对高浓度甲泼尼龙的斑贴试验反应为阴性，但用这种皮质类固醇进行皮内试验很容易证明存在迟发型超敏反应。两名患者对市售皮质类固醇混悬液中的一种专利防腐剂（肉豆蔻基γ-吡啶鎓氯化物）也伴有迟发型超敏反应，这通过皮内试验得到了证实。这些观察结果（斑贴试验反应阴性，皮内试验反应阳性）表明给药途径可能是抗原性半抗原-蛋白质复合物形成以及随后涉及皮肤或黏膜皮肤组织的迟发型超敏反应的一个重要决定因素。
