Mabena Ntokozo, Rugbeer Nivash, Lehmann Sandra, Torres Georgia, Patel Deepak, Mabunda Mosima, Greyling Mike, Thornton Jane S, Choi Yun-Hee, Stranges Saverio, Patricios Jon S
Discovery Vitality, Sandton, South Africa.
Physiology, Division of Biokinetics and Sports Science, University of Pretoria, Pretoria, South Africa.
Br J Sports Med. 2025 May 2;59(10):715-721. doi: 10.1136/bjsports-2024-108813.
This study aimed to determine the association between progression and mortality in individuals with stage 1 cancer and their recorded physical activity before the diagnosis of the cancer.
We included 28 248 members with stage 1 cancers enrolled in an oncology programme in South Africa. Physical activity was recorded using fitness devices, logged gym sessions and participation in organised fitness events. Levels of physical activity over the 12 months before cancer diagnosis were categorised as no physical activity, low physical activity (an average of <60 min/week) and moderate to high physical activity (≥60 min/week). Measured outcomes were time to progression, time to death and all cause mortality.
Physically active members showed lower rates of cancer progression and lower rates of death from all causes. The HR for progression to higher stages or death was 0.84 (95% CI 0.79 to 0.89), comparing low activity with no physical activity, and 0.73 (95% CI 0.70 to 0.77), comparing medium to high physical activity with no physical activity. The HR for all cause mortality was 0.67 (95% CI 0.61 to 0.74), comparing low physical activity with no activity, and 0.53 (95% CI 0.50 to 0.58), comparing medium to high physical activity with no physical activity.
Individuals engaging in any level of recorded physical activity showed a reduced risk of cancer progression or mortality than those not physically active. There was a further reduction among individuals with moderate to high levels of physical activity compared with those with lower levels.
本研究旨在确定1期癌症患者病情进展和死亡率与癌症诊断前记录的身体活动之间的关联。
我们纳入了28248名参加南非肿瘤学项目的1期癌症患者。使用健身设备记录身体活动情况，记录健身房锻炼次数以及参与有组织的健身活动情况。将癌症诊断前12个月的身体活动水平分为无身体活动、低身体活动（平均每周<60分钟）和中度至高度身体活动（≥60分钟/周）。测量的结果包括病情进展时间、死亡时间和全因死亡率。
身体活跃的患者癌症进展率和全因死亡率较低。低身体活动组与无身体活动组相比，进展到更高阶段或死亡的风险比（HR）为0.84（95%置信区间0.79至0.89）；中度至高度身体活动组与无身体活动组相比，该HR为0.73（95%置信区间0.70至0.77）。低身体活动组与无身体活动组相比，全因死亡率的HR为0.67（95%置信区间0.61至0.74）；中度至高度身体活动组与无身体活动组相比，该HR为0.53（95%置信区间0.50至0.58）。
与不进行身体活动的人相比，进行任何水平记录的身体活动的个体癌症进展或死亡风险降低。与低水平身体活动的个体相比，中度至高度身体活动的个体风险进一步降低。
