Izquierdo M, Mateo I, Rodrígo M, Mena C, Sebastián M, Conde J, Gómez-Reino J J
Ann Rheum Dis. 1985 Feb;44(2):98-103. doi: 10.1136/ard.44.2.98.
The clinical manifestations in 21 children with chronic toxic epidemic syndrome (TES) and musculoskeletal manifestations were analysed and compared with those of the adult population. The sex ratio (2.5:1, F/M) was different from the one found in adults (6:1, F/M). The neuromuscular syndrome, the scleroderma-like picture, the pulmonary hypertension, and the Raynaud's phenomenon characteristic of TES were similar to those in adults but milder in children. The less severe vascular endothelial lesions found on microscopic examination might explain the better prognosis in this age group.
对21例患有慢性中毒性流行综合征（TES）并伴有肌肉骨骼表现的儿童的临床表现进行了分析，并与成人患者的临床表现进行了比较。其性别比为2.5:1（女/男），与成人患者不同（6:1，女/男）。TES特有的神经肌肉综合征、硬皮病样表现、肺动脉高压和雷诺现象与成人相似，但在儿童中症状较轻。显微镜检查发现的血管内皮病变较轻，这可能解释了该年龄组预后较好的原因。
