Eljezi Vedat, Jallas Crispin, Pereira Bruno, Chasteloux Melanie, Dualé Christian, Camilleri Lionel
Department of Perioperative Medicine, CHU Gabriel-Montpied, Rue Montalembert, BP 69, 63003 Clermont-Ferrand, France.
Departement of Anaesthesia, Hôspital Femme Mère Enfant, 59 Boulevard Pinel, 69500 Bron, France.
Ann Card Anaesth. 2025 Jan 1;28(1):39-45. doi: 10.4103/aca.aca_110_24. Epub 2024 Nov 19.
The aim of this study was to assess whether parasternal block with multihole catheters inserted before surgical incision enables to alleviate postoperative analgesia and opioid reduction in cardiac surgery patients with sternotomy.
Twenty-six adult patients scheduled for cardiac surgery with sternotomy aged between 18 and 84 olds were included in this prospective, monocentric, open, single-group trial. Two parasternal multihole catheters were inserted on each side of the sternum before the surgical skin incision for cardiac surgery and 10 mL of ropivacaine 7.5 mg mL -1 was initially administered in each catheter. Local anesthetic administration followed by continued infusion at 3 mL hr -1 of ropivacaine 2 mg mL -1 per catheter for 48 h postoperatively upon patient arrival in the intensive care unit. The efficacy of the parasternal block was assessed according to a composite endpoint including pain score at rest, pain score during movements (dynamic pain), and morphine consumption over 48 hours.
The treatment failed in 11 patients and was considered effective in 15 patients. Sixteen patients out of 26 had a sternal pain score ≤≤3/10 on more than 75% of observations, and the treatment was considered successful. In 23/26 patients (88%), the mean pain score at cough was ≤≤3.5/10 and the treatment was considered successful. Morphine consumption over 48 h was significantly lower in the intervention group compared to the control group 7 mg [6; 21] versus 142 mg [116; 176] ( P < 0.001).
Parasternal block with multihole catheters inserted before the surgical incision is an effective technique for postoperative analgesia and opioid reduction.
本研究旨在评估在手术切口前插入多孔导管进行胸骨旁阻滞是否能够减轻胸骨切开术心脏手术患者的术后疼痛并减少阿片类药物的使用。
本前瞻性、单中心、开放性、单组试验纳入了26例计划行胸骨切开术心脏手术的成年患者,年龄在18至84岁之间。在心脏手术的皮肤切口前,于胸骨两侧各插入一根胸骨旁多孔导管,初始时每根导管注入10 mL浓度为7.5 mg/mL的罗哌卡因。患者进入重症监护病房后,术后48小时内每根导管以3 mL/h的速度持续输注浓度为2 mg/mL的罗哌卡因。根据包括静息时疼痛评分、活动时疼痛评分(动态疼痛)以及48小时内吗啡消耗量的综合终点来评估胸骨旁阻滞的疗效。
11例患者治疗失败,15例患者治疗有效。26例患者中有16例在超过75%的观察中胸骨疼痛评分≤3/10,治疗被认为成功。23/26例患者(88%)咳嗽时的平均疼痛评分≤3.5/10,治疗被认为成功。干预组48小时内的吗啡消耗量显著低于对照组,分别为7 mg [6; 21] 与142 mg [116; 176] (P < 0.001)。
手术切口前插入多孔导管进行胸骨旁阻滞是一种有效的术后镇痛和减少阿片类药物使用的技术。