Sękowska Alicja
Department of Microbiology, Nicolaus Copernicus University, The Ludwik Rydygiers Collegium Medicum, Bydgoszcz, Poland.
Department of Clinical Microbiology, University Hospital No. 1, Bydgoszcz, Poland.
J Antibiot (Tokyo). 2025 Feb;78(3):197-202. doi: 10.1038/s41429-024-00803-6. Epub 2025 Jan 7.
Klebsiella pneumoniae complex (KPc) is a group of opportunistic pathogens that pose a serious threat to public health. Multidrug resistance is increasing, and limiting therapeutic options. Aztreonam-avibactam (AZA) is a combination of an established β-lactam with a new β-lactamase inhibitor. The aim of this study was to assess the susceptibility of multidrug-resistant KPc strains to AZA. The study included 52 ESβL-positive strains and 152 carbapenemase-positive KPc strains. The susceptibility to AZA was tested using the gradient strip method. AZA showed high activity against KPc, with MICs ranging from 0.032 to 0.75 μg ml for ESβL-positive strains and from 0.016 to 2 μg ml for carbapenemase-positive strains. The lowest MIC of AZA was obtained for VIM- and ESβL-positive strains at 0.094 μg ml, and MIC for ESβL-positive strains was 0.125 μg ml. AZA demonstrated excellent in vitro activity against the analysed strains, suggesting that this antibiotic may be an effective therapeutic option for treating infections caused by multidrug-resistant KPc strains.
肺炎克雷伯菌复合体（KPc）是一组对公共卫生构成严重威胁的机会性病原体。多重耐药性不断增加，限制了治疗选择。氨曲南-阿维巴坦（AZA）是一种已有的β-内酰胺与新型β-内酰胺酶抑制剂的组合。本研究的目的是评估多重耐药性KPc菌株对AZA的敏感性。该研究纳入了52株产超广谱β-内酰胺酶（ESβL）阳性菌株和152株碳青霉烯酶阳性KPc菌株。使用梯度纸条法检测对AZA的敏感性。AZA对KPc显示出高活性，ESβL阳性菌株的最低抑菌浓度（MIC）范围为0.032至0.75μg/ml，碳青霉烯酶阳性菌株的MIC范围为0.016至2μg/ml。VIM和ESβL阳性菌株的AZA最低MIC为0.094μg/ml，ESβL阳性菌株的MIC为0.125μg/ml。AZA对分析的菌株表现出优异的体外活性，表明这种抗生素可能是治疗多重耐药性KPc菌株引起的感染的有效治疗选择。
