Qiyuan Pang, Changyang Lin, Gaigai Li, Ju Qiu, Xun Zhou
Department of Nursing, Guiyang Hospital of Stomatology, Guiyang, China.
Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China.
PLoS One. 2024 Dec 30;19(12):e0312099. doi: 10.1371/journal.pone.0312099. eCollection 2024.
To evaluate the prognostic role of procalcitonin(PCT) on all-cause mortality in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
Database including PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched to find relevant trials. We included studies with patients hospitalized for AECOPD, which assessed procalcitonin levels and reported on the association between procalcitonin and mortality..
Fourteen trials involving 2983 patients were included. We found PCT levels in patients hospitalized for AECOPD are not associated with increased risk of mortality (RR 1.03, 95%CI 0.99-1.08). However, subgroup analysis showed PCT levels are indeed associated with an increased risk of mortality in mild to moderate AECOPD(RR 1.74, 95%CI 1.11-2.73). Deceased patients had significantly higher PCT levels, compared to survivors (MD 0.61, 95%CI 0.30-0.92). In PCT positive group, there was a significant increase in all-cause mortality(OR 3.21, 95%CI 1.84-5.61).
Results from this meta-analysis suggest that procalcitonin levels at the time of hospital admission for mild to moderate AECOPD are positively correlated with mortality.
评估降钙素原（PCT）对慢性阻塞性肺疾病急性加重期（AECOPD）全因死亡率的预后作用。
检索包括PubMed、EMBASE和Cochrane对照试验中央注册库在内的数据库以查找相关试验。我们纳入了因AECOPD住院的患者的研究，这些研究评估了降钙素原水平并报告了降钙素原与死亡率之间的关联。
纳入了14项涉及2983例患者的试验。我们发现因AECOPD住院的患者的PCT水平与死亡风险增加无关（风险比1.03，95%置信区间0.99 - 1.08）。然而，亚组分析显示PCT水平在轻度至中度AECOPD中确实与死亡风险增加相关（风险比1.74，95%置信区间1.11 - 2.73）。与幸存者相比，死亡患者的PCT水平显著更高（平均差0.61，95%置信区间0.30 - 0.92）。在PCT阳性组中，全因死亡率显著增加（比值比3.21，95%置信区间1.84 - 5.61）。
这项荟萃分析的结果表明，轻度至中度AECOPD入院时的降钙素原水平与死亡率呈正相关。
