Binh Nguyen Thai, Hien Phan Nhan, Linh Nguyen Truc, Linh Le Tuan
Radiology Department, Hanoi Medical University, 1st Ton That Tung Streets, Dong Da, Hanoi, 10000, Vietnam.
Radiology Center, Hanoi Medical University Hospital, Hanoi Medical University, 1st Ton That Tung Streets, Dong Da, Hanoi, 10000, Vietnam.
Cardiovasc Intervent Radiol. 2025 Mar;48(3):364-371. doi: 10.1007/s00270-024-03954-z. Epub 2025 Jan 8.
To evaluate the feasibility and diagnostic value of percutaneous transhepatic cholangioscopy biopsy (PTCB) for identifying the causes of biliary strictures.
This retrospective study included 34 patients (18 females and 16 males), with a mean age of 59.4 ± 13 years. The study population consisted of patients with suspected malignant biliary strictures on imaging or biliary lesions suspected of malignancy during percutaneous transhepatic endoscopic biliary lithotripsy (PTEBL). The final diagnosis for each patient was confirmed based on surgical pathology results, additional histopathological data, or through close clinical and imaging follow-up for at least one year.
Among the patients, 20 (58.9%) underwent PTCB alone, while 14 (41.1%) underwent PTCB combined with PTEBL. Biopsy locations included: 12 patients (35.3%) with intrahepatic bile duct, 12 patients (35.3%) with hilar bile duct, and 10 patients (29.4%) with common bile duct. Technical success of PTCB was defined as successful access to the biliary lesion, with the collection of an adequate histopathological tissue sample achieved in 100% of patients. The sensitivity, specificity, and accuracy of PTCB were 90%, 100%, and 97.1%, respectively. Minor complications were observed in 3 patients (8.8%).
PTCB is a feasible and effective method for diagnosing the causes of biliary strictures, offering high sensitivity, specificity, and accuracy.
评估经皮经肝胆道镜活检（PTCB）在鉴别胆道狭窄病因方面的可行性及诊断价值。
本回顾性研究纳入34例患者（18例女性，16例男性），平均年龄59.4±13岁。研究对象包括影像学检查怀疑为恶性胆道狭窄的患者或在经皮经肝内镜胆道碎石术（PTEBL）期间怀疑为恶性的胆道病变患者。每位患者的最终诊断依据手术病理结果、额外的组织病理学数据或至少一年的密切临床及影像学随访确定。
患者中，20例（58.9%）仅接受了PTCB，14例（41.1%）接受了PTCB联合PTEBL。活检部位包括：肝内胆管12例（35.3%），肝门胆管12例（35.3%），胆总管10例（2).4%）。PTCB的技术成功定义为成功进入胆道病变，100%的患者获得了足够的组织病理学样本。PTCB的敏感性、特异性和准确性分别为90%、100%和97.1%。3例患者（8.8%）出现轻微并发症。
PTCB是诊断胆道狭窄病因的一种可行且有效的方法，具有较高的敏感性
