Mo De-Gang, Liang Ming-Ting, Xu Li, Li Tai, Han Qian-Feng, Chen Chen, Yao Heng-Chen
Department of Cardiology, Qingdao University, Qingdao, 266000, China.
Department of Cardiology, Liaocheng People's Hospital Affiliated to Shandong First Medical University, Liaocheng, 252000, China.
Sci Rep. 2025 Jan 7;15(1):1187. doi: 10.1038/s41598-024-85041-4.
The NOD‑like receptor protein domain associated protein 3 (NLRP3) inflammasome is critical in inflammatory responses and may be a valuable prognostic biomarker in acute coronary syndrome (ACS). We aimed to investigate the association between NLRP3 inflammasome levels and short-term outcomes in patients with ACS. We enrolled 295 patients with ACS who were monitored for 6 months for major adverse cardiovascular events (MACEs). The NLRP3 inflammasome was quantified using enzyme-linked immunosorbent assays, with the Gensini score used to assess disease severity. A Cox regression model evaluated whether NLRP3 inflammasome levels were independent predictors of MACEs. Spearman correlation analysis demonstrated a significant positive correlation between NLRP3 inflammasome levels and the Gensini score (r = 0.55, p < 0.001). Plasma NLRP3 inflammasome levels were significantly higher in the MACEs group (8.48 ng/mL) compared with the no-MACEs group (3.48 ng/mL) (p < 0.001). Multivariate Cox regression identified NLRP3 inflammasome content as an independent risk factor for MACEs (hazard ratio 1.104, p = 0.001; area under the curve: 0.780 [95% confidence interval 0.721-0.840], p < 0.001). Elevated plasma NLRP3 inflammasome levels correlated with ACS severity and were associated with poorer short-term outcomes in patients with ACS.
核苷酸结合寡聚化结构域样受体蛋白3（NLRP3）炎性小体在炎症反应中起关键作用，可能是急性冠状动脉综合征（ACS）中有价值的预后生物标志物。我们旨在研究ACS患者中NLRP3炎性小体水平与短期预后之间的关联。我们纳入了295例ACS患者，对其进行了6个月的主要不良心血管事件（MACE）监测。使用酶联免疫吸附测定法对NLRP3炎性小体进行定量，采用Gensini评分评估疾病严重程度。Cox回归模型评估NLRP3炎性小体水平是否为MACE的独立预测因子。Spearman相关性分析表明，NLRP3炎性小体水平与Gensini评分之间存在显著正相关（r = 0.55，p < 0.001）。与无MACE组（3.48 ng/mL）相比，MACE组的血浆NLRP3炎性小体水平显著更高（8.48 ng/mL）（p < 0.001）。多变量Cox回归确定NLRP3炎性小体含量是MACE的独立危险因素（风险比1.104，p = 0.001；曲线下面积：0.780 [95%置信区间0.721 - 0.840]，p < 0.001）。血浆NLRP3炎性小体水平升高与ACS严重程度相关，并与ACS患者较差的短期预后相关。
