Alving B M, Strickler M P, Knight R D, Barr C F, Berenberg J L, Peck C C
Arch Intern Med. 1985 Mar;145(3):499-501.
A 57-year-old black woman required a daily dosage of 50 mg of warfarin sodium to maintain her prothrombin time in a therapeutic range. The central volume of distribution and clearance of warfarin were normal for this patient. These findings, combined with the patient's requirement for plasma warfarin levels four times greater than those usually required to achieve adequate anticoagulation, indicated that the relative resistance was due to altered pharmacodynamics of warfarin. The only child of the propositus, a daughter, showed a similar relative resistance, confirming that this family is the third to be reported with hereditary resistance to warfarin.
一名57岁的黑人女性需要每日服用50毫克华法林钠，以将其凝血酶原时间维持在治疗范围内。该患者华法林的分布容积和清除率均正常。这些发现，再加上患者所需的血浆华法林水平是通常达到充分抗凝所需水平的四倍，表明这种相对抵抗是由于华法林药效学改变所致。先证者的独生女也表现出类似的相对抵抗，证实这个家族是第三例被报道的对华法林具有遗传性抵抗的家族。
