Amiri Mohammad, Hashemi Zahra, Chekin Fereshteh
Department of Pharmacy, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
J Mater Sci Mater Med. 2025 Jan 7;36(1):4. doi: 10.1007/s10856-024-06847-2.
The antimalarial hydroxychloroquine (HCQ) has considered for the treatment of systemic lupus erythematosus. Moreover, HCQ has been used as a drug to treat Coronavirus disease (COVID-19). In this work, nitrogen doped porous reduced graphene oxide (NprGO) has been prepared via environmentally friendly process using Fummaria Parviflora extract. A catalyst based on ZnO nanoparticles-nitrogen doped porous reduced graphene oxide (ZnO-NprGO) was prepared by hydrothermal method and characterized. The diameter of ZnO nanoparticles was ~22-37 nm, which were inserted between the NprGO sheets effectively prevented their aggregation. The ZnO-NprGO hybrid had high surface area and good electro-catalytic property, suiting for determination of HCQ. The ZnO-NprGO modified carbon paste electrode (CPE)-based sensor operated in a wide concentration range of 0.07-5.5 μmol L with low limit of detection of 57 nmol L and sensitivity of 14.175 μA μmol L. Remarkably, the ZnO-NprGO/CPE sensor indicated acceptable accuracy, reproducibility, and stability. In addition, the proposed sensor was applied to detection of HCQ in biological samples and the recoveries were 92.0-102.5%, with relative standard deviations of 1.9-4.3%. The unique physical structure of ZnO-NprGO, as well as its chemical and electrical properties, make it promising interface for use in sensors and nanoelectronic applications.
抗疟药羟氯喹（HCQ）已被考虑用于治疗系统性红斑狼疮。此外，HCQ还被用作治疗冠状病毒病（COVID-19）的药物。在这项工作中，使用小花荷包牡丹提取物通过环境友好的工艺制备了氮掺杂多孔还原氧化石墨烯（NprGO）。通过水热法制备了一种基于氧化锌纳米颗粒-氮掺杂多孔还原氧化石墨烯（ZnO-NprGO）的催化剂并对其进行了表征。氧化锌纳米颗粒的直径约为22-37纳米，它们有效地插入到NprGO片层之间，防止了它们的聚集。ZnO-NprGO杂化物具有高表面积和良好的电催化性能，适合用于测定HCQ。基于ZnO-NprGO修饰碳糊电极（CPE）的传感器在0.07-5.5 μmol/L的宽浓度范围内运行，检测限低至57 nmol/L，灵敏度为14.175 μA/μmol/L。值得注意的是，ZnO-NprGO/CPE传感器具有可接受的准确性、重现性和稳定性。此外，所提出的传感器应用于生物样品中HCQ的检测，回收率为92.0-102.5%，相对标准偏差为1.9-4.3%。ZnO-NprGO独特的物理结构及其化学和电学性质使其成为用于传感器和纳米电子应用的有前途的界面。
